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    Flt1 FMS-like tyrosine kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14254, updated on 27-Nov-2024

    Summary

    Official Symbol
    Flt1provided by MGI
    Official Full Name
    FMS-like tyrosine kinase 1provided by MGI
    Primary source
    MGI:MGI:95558
    See related
    Ensembl:ENSMUSG00000029648 AllianceGenome:MGI:95558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Flt-1; sFlt1; VEGFR1; VEGFR-1
    Summary
    Enables identical protein binding activity and vascular endothelial growth factor receptor activity. Involved in several processes, including blood vessel morphogenesis; embryonic morphogenesis; and hyaloid vascular plexus regression. Acts upstream of or within several processes, including angiogenesis; positive regulation of hematopoietic progenitor cell differentiation; and post-embryonic camera-type eye morphogenesis. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; bronchopulmonary dysplasia; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 35.7), lung adult (RPKM 11.8) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Flt1 in Genome Data Viewer
    Location:
    5 G3; 5 87.01 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147498414..147663419, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147561604..147726438, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8093 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:148238101-148238295 Neighboring gene DNA segment, Chr 5, ERATO Doi 605, expressed Neighboring gene PAN3 poly(A) specific ribonuclease subunit Neighboring gene STARR-positive B cell enhancer ABC_E2773 Neighboring gene predicted gene, 35383 Neighboring gene STARR-seq mESC enhancer starr_14879 Neighboring gene STARR-seq mESC enhancer starr_14882 Neighboring gene predicted gene, 35541 Neighboring gene predicted gene, 35592

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GPI-linked ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables boss receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables brain-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables epidermal growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hepatocyte growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin-like growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables macrophage colony-stimulating factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables placental growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables placental growth factor receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables platelet-derived growth factor alpha-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables platelet-derived growth factor beta-receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein tyrosine kinase collagen receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables stem cell factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane-ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables vascular endothelial growth factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables vascular endothelial growth factor receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables vascular endothelial growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables vascular endothelial growth factor receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables vascular endothelial growth factor receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in Kit signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within branching involved in blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hyaloid vascular plexus regression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in macrophage colony-stimulating factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic camera-type eye morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sprouting angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vascular endothelial growth factor receptor-1 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    vascular endothelial growth factor receptor 1
    Names
    embryonic receptor kinase 2
    tyrosine-protein kinase receptor FLT
    vascular permeability factor receptor
    NP_001350064.1
    NP_034358.2
    XP_006504864.1
    XP_006504865.1
    XP_006504866.1
    XP_011239302.1
    XP_036020680.1
    XP_036020681.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363135.1NP_001350064.1  vascular endothelial growth factor receptor 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC131730, AK013236, AK167497, BP763953
      Consensus CDS
      CCDS90022.1
      UniProtKB/TrEMBL
      O55095, Q3TJC1, Q8K1H4
      Related
      ENSMUSP00000106158.2, ENSMUST00000110529.6
      Conserved Domains (4) summary
      smart00408
      Location:570641
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:144220
      IG; Immunoglobulin
      pfam13927
      Location:428540
      Ig_3; Immunoglobulin domain
      cl11960
      Location:354425
      Ig; Immunoglobulin domain
    2. NM_010228.4NP_034358.2  vascular endothelial growth factor receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034358.2

      Status: VALIDATED

      Source sequence(s)
      AC122299, AC131730
      Consensus CDS
      CCDS19879.1
      UniProtKB/Swiss-Prot
      O55094, P35969, Q61517
      UniProtKB/TrEMBL
      A0A0R4J0A4
      Related
      ENSMUSP00000031653.6, ENSMUST00000031653.12
      Conserved Domains (8) summary
      cd00096
      Location:452550
      Ig; Immunoglobulin domain
      smart00408
      Location:677739
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:570641
      IG; Immunoglobulin
      smart00410
      Location:238329
      IG_like; Immunoglobulin like
      pfam07679
      Location:662749
      I-set; Immunoglobulin I-set domain
      pfam07714
      Location:8281154
      Pkinase_Tyr; Protein tyrosine kinase
      cl11960
      Location:354425
      Ig; Immunoglobulin domain
      cl21453
      Location:8201157
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      147498414..147663419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164787.1XP_036020680.1  vascular endothelial growth factor receptor 1 isoform X2

      Conserved Domains (4) summary
      smart00408
      Location:475
      IGc2; Immunoglobulin C-2 Type
      pfam07679
      Location:96183
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:114117
      Ig; Ig strand B [structural motif]
      cl21453
      Location:254591
      PKc_like; Protein Kinases, catalytic domain
    2. XM_011241000.4XP_011239302.1  vascular endothelial growth factor receptor 1 isoform X3

      UniProtKB/TrEMBL
      Q3TJC1, Q8K1H4
      Conserved Domains (5) summary
      smart00408
      Location:570641
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:144220
      IG_like; Immunoglobulin like
      pfam07679
      Location:662749
      I-set; Immunoglobulin I-set domain
      pfam13927
      Location:429540
      Ig_3; Immunoglobulin domain
      cl11960
      Location:354425
      Ig; Immunoglobulin domain
    3. XM_006504801.5XP_006504864.1  vascular endothelial growth factor receptor 1 isoform X1

      Conserved Domains (4) summary
      smart00408
      Location:570641
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:144220
      IG; Immunoglobulin
      pfam13927
      Location:429540
      Ig_3; Immunoglobulin domain
      cl11960
      Location:354425
      Ig; Immunoglobulin domain
    4. XM_006504802.5XP_006504865.1  vascular endothelial growth factor receptor 1 isoform X4

      UniProtKB/TrEMBL
      Q3TJC1, Q8K1H4
      Conserved Domains (4) summary
      smart00408
      Location:570641
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:144220
      IG_like; Immunoglobulin like
      pfam13927
      Location:429540
      Ig_3; Immunoglobulin domain
      cl11960
      Location:354425
      Ig; Immunoglobulin domain
    5. XM_006504803.5XP_006504866.1  vascular endothelial growth factor receptor 1 isoform X5

      UniProtKB/TrEMBL
      Q3TJC1, Q8K1H4
      Conserved Domains (4) summary
      smart00408
      Location:570641
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:144220
      IG; Immunoglobulin
      pfam13927
      Location:429540
      Ig_3; Immunoglobulin domain
      cl11960
      Location:354425
      Ig; Immunoglobulin domain
    6. XM_036164788.1XP_036020681.1  vascular endothelial growth factor receptor 1 isoform X6

      UniProtKB/TrEMBL
      Q9DAV2
      Conserved Domains (4) summary
      smart00410
      Location:144220
      IG_like; Immunoglobulin like
      pfam13927
      Location:428468
      Ig_3; Immunoglobulin domain
      cd00096
      Location:334338
      Ig; Ig strand A [structural motif]
      cl11960
      Location:334425
      Ig; Immunoglobulin domain

    RNA

    1. XR_004942438.1 RNA Sequence