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    Hk2 hexokinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 15277, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hk2provided by MGI
    Official Full Name
    hexokinase 2provided by MGI
    Primary source
    MGI:MGI:1315197
    See related
    Ensembl:ENSMUSG00000000628 AllianceGenome:MGI:1315197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HKII
    Summary
    Enables hexokinase activity. Involved in negative regulation of mitochondrial membrane permeability and negative regulation of reactive oxygen species metabolic process. Acts upstream of or within several processes, including carbohydrate phosphorylation; cellular response to leukemia inhibitory factor; and regulation of D-glucose import. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human HK2 (hexokinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 28.6), genital fat pad adult (RPKM 13.1) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Hk2 in Genome Data Viewer
    Location:
    6 C3; 6 35.94 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (82702004..82751437, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (82725025..82774454, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32534 Neighboring gene predicted gene, 32480 Neighboring gene STARR-seq mESC enhancer starr_16449 Neighboring gene predicted gene, 38843 Neighboring gene predicted gene, 32591

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables D-glucose binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables D-glucose binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables fructokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fructokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fructokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables glucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glucokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hexokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables hexokinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables hexokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hexokinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic mitochondrial changes IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic mitochondrial changes ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within carbohydrate phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in carbohydrate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in establishment of protein localization to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fructose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fructose 6-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glucose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucose 6-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of protein location in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in maintenance of protein location in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mitochondrial membrane permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type 2 mitophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of type 2 mitophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of D-glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ischemia ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hexokinase-2
    Names
    HK II
    hexokinase type II
    NP_038848.1
    XP_017176890.1
    XP_036021773.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013820.4NP_038848.1  hexokinase-2

      See identical proteins and their annotated locations for NP_038848.1

      Status: VALIDATED

      Source sequence(s)
      AC116811
      Consensus CDS
      CCDS20263.1
      UniProtKB/Swiss-Prot
      O08528
      UniProtKB/TrEMBL
      E9Q5B5
      Related
      ENSMUSP00000000642.5, ENSMUST00000000642.11
      Conserved Domains (3) summary
      PTZ00107
      Location:12460
      PTZ00107; hexokinase; Provisional
      pfam00349
      Location:21219
      Hexokinase_1; Hexokinase
      pfam03727
      Location:673907
      Hexokinase_2; Hexokinase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      82702004..82751437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321401.3XP_017176890.1  hexokinase-2 isoform X1

      UniProtKB/TrEMBL
      E9Q5B5
      Conserved Domains (2) summary
      pfam00349
      Location:365561
      Hexokinase_1
      pfam03727
      Location:567801
      Hexokinase_2
    2. XM_036165880.1XP_036021773.1  hexokinase-2 isoform X1

      UniProtKB/TrEMBL
      E9Q5B5
      Conserved Domains (2) summary
      pfam00349
      Location:365561
      Hexokinase_1
      pfam03727
      Location:567801
      Hexokinase_2