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    Zfp668 zinc finger protein 668 [ Mus musculus (house mouse) ]

    Gene ID: 244219, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp668provided by MGI
    Official Full Name
    zinc finger protein 668provided by MGI
    Primary source
    MGI:MGI:2442943
    See related
    Ensembl:ENSMUSG00000049728 AllianceGenome:MGI:2442943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf668; E130018B19Rik
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF668 (zinc finger protein 668). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 4.7), whole brain E14.5 (RPKM 3.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp668 in Genome Data Viewer
    Location:
    7 F3; 7 69.79 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127460197..127476008, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127861025..127876836, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene syntaxin 1B Neighboring gene STARR-positive B cell enhancer ABC_E3755 Neighboring gene syntaxin 4A (placental) Neighboring gene STARR-seq mESC enhancer starr_20194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:135020325-135020434 Neighboring gene zinc finger protein 646 Neighboring gene serine protease 53 Neighboring gene vitamin K epoxide reductase complex, subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptional suppression of interleukin-12 gene expression following phagocytosis of apoptotic cells. Kim S, et al. Immunity, 2004 Nov. PMID 15539151
    2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC40890

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 668

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362189.1 → NP_001349118.1  zinc finger protein 668

      Status: VALIDATED

      Source sequence(s)
      AC149222
      Consensus CDS
      CCDS21881.1
      UniProtKB/Swiss-Prot
      Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
      Related
      ENSMUSP00000101870.2, ENSMUST00000106263.8
      Conserved Domains (2) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001362190.1 → NP_001349119.1  zinc finger protein 668

      Status: VALIDATED

      Source sequence(s)
      AC149222
      Consensus CDS
      CCDS21881.1
      UniProtKB/Swiss-Prot
      Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
      Related
      ENSMUSP00000101869.2, ENSMUST00000106262.2
      Conserved Domains (2) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001362191.1 → NP_001349120.1  zinc finger protein 668

      Status: VALIDATED

      Source sequence(s)
      AC149222
      Consensus CDS
      CCDS21881.1
      UniProtKB/Swiss-Prot
      Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
      Related
      ENSMUSP00000101868.2, ENSMUST00000106261.8
      Conserved Domains (2) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001362192.1 → NP_001349121.1  zinc finger protein 668

      Status: VALIDATED

      Source sequence(s)
      AC149222
      Consensus CDS
      CCDS21881.1
      UniProtKB/Swiss-Prot
      Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
      Conserved Domains (2) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_146259.4 → NP_666371.1  zinc finger protein 668

      See identical proteins and their annotated locations for NP_666371.1

      Status: VALIDATED

      Source sequence(s)
      AC149222, AK053438, BB612340
      Consensus CDS
      CCDS21881.1
      UniProtKB/Swiss-Prot
      Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
      Related
      ENSMUSP00000056105.6, ENSMUST00000054415.12
      Conserved Domains (2) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127460197..127476008 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322256.3 → XP_017177745.1  zinc finger protein 668 isoform X1

      UniProtKB/Swiss-Prot
      Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
      Conserved Domains (2) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_036153124.1 → XP_036009017.1  zinc finger protein 668 isoform X1

      UniProtKB/Swiss-Prot
      Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
      Conserved Domains (2) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_006507848.4 → XP_006507911.1  zinc finger protein 668 isoform X1

      See identical proteins and their annotated locations for XP_006507911.1

      UniProtKB/Swiss-Prot
      Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
      Conserved Domains (2) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_006507851.5 → XP_006507914.1  zinc finger protein 668 isoform X1

      See identical proteins and their annotated locations for XP_006507914.1

      UniProtKB/Swiss-Prot
      Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
      Conserved Domains (2) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_006507850.4 → XP_006507913.1  zinc finger protein 668 isoform X1

      See identical proteins and their annotated locations for XP_006507913.1

      UniProtKB/Swiss-Prot
      Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
      Conserved Domains (2) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_030242589.2 → XP_030098449.1  zinc finger protein 668 isoform X1

      UniProtKB/Swiss-Prot
      Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
      Conserved Domains (2) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_036153123.1 → XP_036009016.1  zinc finger protein 668 isoform X1

      UniProtKB/Swiss-Prot
      Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
      Conserved Domains (2) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_017322254.3 → XP_017177743.1  zinc finger protein 668 isoform X1

      UniProtKB/Swiss-Prot
      Q3TEM2, Q3U7Y5, Q8C8B7, Q8K2R5
      Conserved Domains (2) summary
      COG5048
      Location:65 → 419
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:226 → 246
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2R5.1 GenPept UniProtKB/Swiss-Prot:Q8K2R5

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