Mtss2 MTSS I-BAR domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mtss2provided by MGI
Official Full Name: MTSS I-BAR domain containing 2provided by MGI
Primary source: MGI:MGI:3039591
See related: Ensembl:ENSMUSG00000033763 AllianceGenome:MGI:3039591
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ABBA; Mtss1l
Summary: Enables actin monomer binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and small GTPase binding activity. Acts upstream of or within lamellipodium organization and membrane organization. Located in several cellular components, including cortical actin cytoskeleton; lamellipodium; and ruffle. Is expressed in several structures, including central nervous system; gut; musculoskeletal system; otic capsule; and vibrissa. Human ortholog(s) of this gene implicated in intellectual developmental disorder with ocular anomalies and distinctive facial features. Orthologous to human MTSS2 (MTSS I-BAR domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cerebellum adult (RPKM 29.3), ovary adult (RPKM 22.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 57.66 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (111447718..111468032)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (110721108..110741401)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results link short-term effects of exercise to activity-dependent expression of Mtss1L, which we propose as a novel effector of activity-dependent rearrangement of synapses.
Title: Exercise-induced enhancement of synaptic function triggered by the inverse BAR protein, Mtss1L.
ABBA promotes cell spreading.
Title: Fibronectin-mediated cell spreading requires ABBA-Rac1 signaling.
This study identifies ABBA as a novel regulator of actin and plasma membrane dynamics in radial glial cells.
Title: ABBA regulates plasma-membrane and actin dynamics to promote radial glia extension.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AA959718 (e-PCR)
- UniSTS:159816

RH125769 (e-PCR)
- UniSTS:142730

AI593503 (e-PCR)
- UniSTS:165600

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin monomer binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to platelet-derived growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to platelet-derived growth factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lamellipodium organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within membrane organization	IDA Inferred from Direct Assay more info	PubMed
involved_in plasma membrane organization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein MTSS 2

Names: MTSS1-like protein; metastasis suppressor 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310591.2 → NP_001297520.1 protein MTSS 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC139245

Consensus CDS

CCDS80930.1

UniProtKB/TrEMBL

D3YWC9

Related

ENSMUSP00000115220.2, ENSMUST00000144041.8

Conserved Domains (1) summary

cl12013
Location:1 → 174

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_001426715.1 → NP_001413644.1 protein MTSS 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC139245
NM_001426716.1 → NP_001413645.1 protein MTSS 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC139245
NM_001426717.1 → NP_001413646.1 protein MTSS 2 isoform 5

Status: VALIDATED

Source sequence(s)

AC139245
NM_001426718.1 → NP_001413647.1 protein MTSS 2 isoform 6

Status: VALIDATED

Source sequence(s)

AC139245
NM_198625.3 → NP_941027.1 protein MTSS 2 isoform 1

See identical proteins and their annotated locations for NP_941027.1

Status: VALIDATED

Source sequence(s)

AC139245

Consensus CDS

CCDS22664.1

UniProtKB/Swiss-Prot

Q6P9S0, Q8C7B7

Related

ENSMUSP00000050211.9, ENSMUST00000052457.15

Conserved Domains (1) summary

cd07643
Location:6 → 236

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

111447718..111468032

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006531011.5 → XP_006531074.1 protein MTSS 2 isoform X1

Conserved Domains (1) summary

cd07643
Location:6 → 239

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
XM_006531012.5 → XP_006531075.1 protein MTSS 2 isoform X2

Conserved Domains (1) summary

cd07643
Location:6 → 239

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
XM_006531015.5 → XP_006531078.1 protein MTSS 2 isoform X5

Conserved Domains (1) summary

cd07643
Location:6 → 239

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
XM_006531016.5 → XP_006531079.1 protein MTSS 2 isoform X6

Conserved Domains (1) summary

cd07643
Location:6 → 239

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
XM_006531017.5 → XP_006531080.1 protein MTSS 2 isoform X8

Conserved Domains (1) summary

cd07643
Location:6 → 208

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
XM_036154045.1 → XP_036009938.1 protein MTSS 2 isoform X9

Conserved Domains (2) summary

cd07643
Location:6 → 208

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

cd22060
Location:683 → 713

WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
XM_036154046.1 → XP_036009939.1 protein MTSS 2 isoform X12

Conserved Domains (2) summary

cd07643
Location:6 → 208

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

cd22060
Location:652 → 682

WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
XM_036154047.1 → XP_036009940.1 protein MTSS 2 isoform X13

Conserved Domains (2) summary

cd07643
Location:6 → 208

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

cd22060
Location:651 → 681

WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
XM_036154048.1 → XP_036009941.1 protein MTSS 2 isoform X15

Conserved Domains (2) summary

cd07643
Location:6 → 205

I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis

cd22060
Location:648 → 678

WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)
XM_006531018.5 → XP_006531081.1 protein MTSS 2 isoform X10

Conserved Domains (1) summary

cl12013
Location:1 → 177

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_030243563.2 → XP_030099423.1 protein MTSS 2 isoform X11

Conserved Domains (1) summary

cl12013
Location:1 → 174

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_030243565.2 → XP_030099425.1 protein MTSS 2 isoform X16

Conserved Domains (1) summary

cl12013
Location:1 → 174

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature