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    Rnf150 ring finger protein 150 [ Mus musculus (house mouse) ]

    Gene ID: 330812, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rnf150provided by MGI
    Official Full Name
    ring finger protein 150provided by MGI
    Primary source
    MGI:MGI:2443860
    See related
    Ensembl:ENSMUSG00000047747 AllianceGenome:MGI:2443860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Greul5; mKIAA1214; A630007N06Rik; C030044C12Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in cranial ganglion; dorsal root ganglion; medulla oblongata basal plate mantle layer; and spinal cord mantle layer. Orthologous to human RNF150 (ring finger protein 150). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 4.6), cortex adult (RPKM 4.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf150 in Genome Data Viewer
    Location:
    8 C2; 8 39.59 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (83589889..83817900)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (82863266..83091271)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5023 Neighboring gene STARR-seq mESC enhancer starr_22070 Neighboring gene zinc finger protein 330 Neighboring gene predicted gene, 31545 Neighboring gene predicted gene, 46045 Neighboring gene STARR-seq mESC enhancer starr_22071 Neighboring gene zinc finger protein 235 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22072 Neighboring gene STARR-positive B cell enhancer mm9_chr8:85599639-85599939 Neighboring gene predicted gene, 53443 Neighboring gene STARR-positive B cell enhancer ABC_E6665 Neighboring gene STARR-seq mESC enhancer starr_22076 Neighboring gene TBC1 domain family, member 9 Neighboring gene predicted gene, 53444 Neighboring gene predicted gene, 42027

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development. Borchers AG, et al. Dev Biol, 2002 Nov 15. PMID 12435366
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1214

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein 150

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177378.4 → NP_796352.2  RING finger protein 150 precursor

      See identical proteins and their annotated locations for NP_796352.2

      Status: VALIDATED

      Source sequence(s)
      AC124757, AC132372, AC166939
      Consensus CDS
      CCDS40402.1
      UniProtKB/Swiss-Prot
      Q5DTZ6
      Related
      ENSMUSP00000077610.6, ENSMUST00000078525.7
      Conserved Domains (3) summary
      cd02122
      Location:45 → 192
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      pfam13639
      Location:275 → 318
      zf-RING_2; Ring finger domain
      cl11506
      Location:206 → 231
      UPF0233; uncharacterized protein family (UPF0233)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      83589889..83817900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154109.1 → XP_036010002.1  RING finger protein 150 isoform X4

      Conserved Domains (2) summary
      cd02122
      Location:45 → 192
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      cl17238
      Location:289 → 313
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_017312865.3 → XP_017168354.1  RING finger protein 150 isoform X1

      Conserved Domains (2) summary
      cd02122
      Location:45 → 192
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      cd16668
      Location:289 → 336
      RING-H2_GRAIL; RING finger, H2 subclass, found in the GRAIL transmembrane proteins family

    3. XM_017312866.3 → XP_017168355.1  RING finger protein 150 isoform X2

      Conserved Domains (2) summary
      cd02122
      Location:1 → 102
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      cd16668
      Location:199 → 246
      RING-H2_GRAIL; RING finger, H2 subclass, found in the GRAIL transmembrane proteins family

    4. XM_030243623.2 → XP_030099483.1  RING finger protein 150 isoform X3

      Conserved Domains (3) summary
      cd02122
      Location:1 → 102
      PA_GRAIL_like; PA _GRAIL_like: Protease-associated (PA) domain GRAIL-like. This group includes PA domain containing E3 (ubiquitin ligases) similar to human GRAIL (gene related to anergy in lymphocytes) protein. Proteins in this group contain a C3H2C3 RING finger. E3 ...
      cd16668
      Location:186 → 233
      RING-H2_GRAIL; RING finger, H2 subclass, found in the GRAIL transmembrane proteins family
      pfam13584
      Location:55 → 169
      BatD; Oxygen tolerance
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DTZ6.2 GenPept UniProtKB/Swiss-Prot:Q5DTZ6

    Gene LinkOut

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