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    Sat1 spermidine/spermine N1-acetyl transferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 20229, updated on 27-Nov-2024

    Summary

    Official Symbol
    Sat1provided by MGI
    Official Full Name
    spermidine/spermine N1-acetyl transferase 1provided by MGI
    Primary source
    MGI:MGI:98233
    See related
    Ensembl:ENSMUSG00000025283 AllianceGenome:MGI:98233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sat; SSAT
    Summary
    Predicted to enable diamine N-acetyltransferase activity; identical protein binding activity; and spermidine binding activity. Acts upstream of or within regulation of cell population proliferation. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human SAT1 (spermidine/spermine N1-acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 89.1), placenta adult (RPKM 43.0) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sat1 in Genome Data Viewer
    Location:
    X F3; X 72.38 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (153996128..153999345, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (155213126..155216449, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 1 Neighboring gene 60S acidic ribosomal protein P0-like Neighboring gene STARR-seq mESC enhancer starr_48134 Neighboring gene ribosomal protein L7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48136 Neighboring gene acyl-CoA thioesterase 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables diamine N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables diamine N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables diamine N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables spermidine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables spermidine binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in polyamine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in polyamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in polyamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in polyamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in putrescine catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in spermidine acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermidine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermidine acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within spermine catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    diamine acetyltransferase 1
    Names
    SSAT-1
    polyamine N-acetyltransferase 1
    putrescine acetyltransferase
    spermidine/spermine N(1)-acetyltransferase 1
    NP_001412931.1
    NP_033147.1
    XP_036017762.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426002.1NP_001412931.1  diamine acetyltransferase 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longer isoform (3).
      Source sequence(s)
      BX119978, BX119986
      UniProtKB/TrEMBL
      A2BES2
      Related
      ENSMUSP00000108170.4, ENSMUST00000112551.4
    2. NM_009121.5NP_033147.1  diamine acetyltransferase 1 isoform 1

      See identical proteins and their annotated locations for NP_033147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      BX119978, BX119986
      Consensus CDS
      CCDS30495.1
      UniProtKB/Swiss-Prot
      P48026, Q3U444
      Related
      ENSMUSP00000026318.9, ENSMUST00000026318.15
      Conserved Domains (1) summary
      pfam00583
      Location:48144
      Acetyltransf_1; Acetyltransferase (GNAT) family

    RNA

    1. NR_189657.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX119978, BX119986
    2. NR_189658.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX119978, BX119986
      Related
      ENSMUST00000152463.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      153996128..153999345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161869.1XP_036017762.1  diamine acetyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      Q3V2Q2
      Related
      ENSMUST00000150046.2
      Conserved Domains (1) summary
      pfam00583
      Location:469
      Acetyltransf_1; Acetyltransferase (GNAT) family