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    Ass1 argininosuccinate synthetase 1 [ Mus musculus (house mouse) ]

    Gene ID: 11898, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ass1provided by MGI
    Official Full Name
    argininosuccinate synthetase 1provided by MGI
    Primary source
    MGI:MGI:88090
    See related
    Ensembl:ENSMUSG00000076441 AllianceGenome:MGI:88090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ASS; fold; Ass-1
    Summary
    Predicted to enable several functions, including argininosuccinate synthase activity; identical protein binding activity; and toxic substance binding activity. Involved in circadian rhythm. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; integumental system; metanephros; and sensory organ. Used to study citrullinemia. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 1308.6), kidney adult (RPKM 838.7) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ass1 in Genome Data Viewer
    Location:
    2 B; 2 21.81 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (31360282..31410682)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31470270..31520670)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:31112123-31112306 Neighboring gene neuronal calcium sensor 1 Neighboring gene STARR-seq mESC enhancer starr_04149 Neighboring gene hemicentin 2 Neighboring gene STARR-positive B cell enhancer ABC_E504 Neighboring gene predicted gene, 32952 Neighboring gene STARR-seq mESC enhancer starr_04154 Neighboring gene predicted gene 13426 Neighboring gene far upstream element (FUSE) binding protein 3 Neighboring gene microRNA 6998

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC103151

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amino acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables argininosuccinate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables argininosuccinate synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables argininosuccinate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables toxic substance binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables toxic substance binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in L-arginine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-arginine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-arginine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in argininosuccinate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in argininosuccinate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in argininosuccinate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aspartate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aspartate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amine stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to ammonium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to glucagon stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to laminar fluid shear stress IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to laminar fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to oleic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in citrulline metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in citrulline metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diaphragm development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in midgut development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of leukocyte cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of leukocyte cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucocorticoid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to growth hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mycotoxin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mycotoxin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to zinc ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to zinc ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in urea cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in urea cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in urea cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in urea cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell body fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body fiber ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myelin sheath HDA PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    argininosuccinate synthase
    Names
    arginosuccinate synthetase 1
    citrulline--aspartate ligase
    NP_031520.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007494.3NP_031520.1  argininosuccinate synthase

      See identical proteins and their annotated locations for NP_031520.1

      Status: VALIDATED

      Source sequence(s)
      AL732564
      Consensus CDS
      CCDS15898.1
      UniProtKB/Swiss-Prot
      P16460
      UniProtKB/TrEMBL
      Q3UEJ7, Q3UJ34
      Related
      ENSMUSP00000099904.5, ENSMUST00000102840.5
      Conserved Domains (1) summary
      pfam00764
      Location:8401
      Arginosuc_synth; Arginosuccinate synthase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      31360282..31410682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)