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    Srgap3 SLIT-ROBO Rho GTPase activating protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 259302, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Srgap3provided by MGI
    Official Full Name
    SLIT-ROBO Rho GTPase activating protein 3provided by MGI
    Primary source
    MGI:MGI:2152938
    See related
    Ensembl:ENSMUSG00000030257 AllianceGenome:MGI:2152938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gbi; WRP; MEGAP; Arhgap14; mKIAA0411; D130026O08Rik
    Summary
    Predicted to enable GTPase activator activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study schizophrenia. Orthologous to human SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 27.6), CNS E18 (RPKM 23.8) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Srgap3 in Genome Data Viewer
    Location:
    6 E3; 6 52.54 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (112694932..112924466, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (112717971..112947505, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11330 Neighboring gene predicted gene, 35824 Neighboring gene predicted gene, 26799 Neighboring gene STARR-seq mESC enhancer starr_17023 Neighboring gene predicted gene, 57496 Neighboring gene STARR-seq mESC enhancer starr_17024 Neighboring gene STARR-seq mESC enhancer starr_17025 Neighboring gene VISTA enhancer mm1480 Neighboring gene STARR-seq mESC enhancer starr_17026 Neighboring gene STARR-positive B cell enhancer mm9_chr6:112812032-112812333 Neighboring gene Yip1 interacting factor homolog A pseudogene Neighboring gene ribosomal protein S29 pseudogene Neighboring gene predicted gene, 23244

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SrGAP3 knockout mice display enlarged lateral ventricles and specific cilia disturbances of ependymal cells in the third ventricle. Koschützke L, et al. Cell Tissue Res, 2015 Aug. PMID 26104135
    2. The mental retardation associated protein, srGAP3 negatively regulates VPA-induced neuronal differentiation of Neuro2A cells. Chen K, et al. Cell Mol Neurobiol, 2011 Jul. PMID 21350945
    3. WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory. Carlson BR, et al. J Neurosci, 2011 Feb 16. PMID 21325512, Free PMC Article
    4. Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes. Waltereit R, et al. FASEB J, 2012 Nov. PMID 22820399
    5. Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. Kim IH, et al. J Biol Chem, 2012 Nov 9. PMID 23007397, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SrGAP3 plays a role in neurodevelopmental disorders.
      Title: Morphological and behavioral characterization of adult mice deficient for SrGAP3.
    2. This study found a more than 15-fold enlargement of the lateral ventricles of homozygous SrGAP3-deficient mice.
      Title: SrGAP3 knockout mice display enlarged lateral ventricles and specific cilia disturbances of ependymal cells in the third ventricle.
    3. SrGAP3 dynamically regulates neuronal cytoskeletal reorganization through inhibition of the Rho GTPase Rac1 and interaction with actin remodeling proteins.
      Title: The cellular function of srGAP3 and its role in neuronal morphogenesis.
    4. The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.
      Title: The inverse F-BAR domain protein srGAP2 acts through srGAP3 to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma cells.
    5. Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus
      Title: Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus.
    6. These results show neurodevelopmental aberration in Srgap3(-/-) mice, with many of the observed phenotypes matching several schizophrenia-related intermediate phenotypes. Mutations of SRGAP3 may thus contribute to various neurodevelopmental disorders.
      Title: Srgap3⁻/⁻ mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes.
    7. Following sciatic nerve transection, srGAP3 in neurons is significantly increased in the ipsilateral relative to contralateral dorsal root ganglions, which peak at day 7 to day 14.
      Title: Slit-Robo GTPase-activating proteins are differentially expressed in murine dorsal root ganglia: modulation by peripheral nerve injury.
    8. srGAP3 is an inhibitor of actin dynamics and lamellipodia formation in primary fibroblasts. srGAP3 influences focal adhesion formation through the downregulation of Rac1.
      Title: SrGAP3 interacts with lamellipodin at the cell membrane and regulates Rac-dependent cellular protrusions.
    9. Data suggest a role for srGAP3 in the lateral positioning of post crossing axons within the ventrolateral funiculus.
      Title: Evidence for a role of srGAP3 in the positioning of commissural axons within the ventrolateral funiculus of the mouse spinal cord.
    10. srGAP3 could regulate neuronal differentiation in a Rac1-dependent manner.
      Title: The mental retardation associated protein, srGAP3 negatively regulates VPA-induced neuronal differentiation of Neuro2A cells.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SLIT-ROBO Rho GTPase-activating protein 3
    Names
    SLIT-ROBO Rho GTPase activating protein 2
    WAVE-associated Rac GTPase-activating protein
    brain stress early protein Gbi
    rho GTPase-activating protein 14
    srGAP2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080448.4 → NP_536696.4  SLIT-ROBO Rho GTPase-activating protein 3

      See identical proteins and their annotated locations for NP_536696.4

      Status: VALIDATED

      Source sequence(s)
      AC153591, AK051262, AY057899, CF744803, CK032058
      Consensus CDS
      CCDS39590.1
      UniProtKB/Swiss-Prot
      Q80U09, Q812A2, Q8BKP4, Q8BLD0, Q925I2
      UniProtKB/TrEMBL
      F8VPQ4
      Related
      ENSMUSP00000085712.5, ENSMUST00000088373.11
      Conserved Domains (3) summary
      cd07684
      Location:26 → 278
      F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
      cd11955
      Location:748 → 800
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:502 → 689
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      112694932..112924466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506145.2 → XP_006506208.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X2

      UniProtKB/Swiss-Prot
      Q80U09, Q812A2, Q8BKP4, Q8BLD0, Q925I2
      UniProtKB/TrEMBL
      E9QN14
      Related
      ENSMUSP00000108794.3, ENSMUST00000113169.9
      Conserved Domains (3) summary
      cd07684
      Location:26 → 278
      F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
      cd11955
      Location:724 → 776
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:481 → 665
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

    2. XM_030255398.1 → XP_030111258.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X4

      Conserved Domains (3) summary
      cd07684
      Location:26 → 278
      F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
      cd11955
      Location:748 → 800
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:502 → 689
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

    3. XM_006506146.2 → XP_006506209.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X3

      Conserved Domains (3) summary
      cd07684
      Location:26 → 278
      F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
      cd11955
      Location:753 → 805
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:510 → 694
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

    4. XM_006506144.2 → XP_006506207.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q80U09, Q812A2, Q8BKP4, Q8BLD0, Q925I2
      Conserved Domains (3) summary
      cd07684
      Location:26 → 278
      F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
      cd11955
      Location:753 → 805
      SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
      cd04383
      Location:510 → 694
      RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

    RNA

    1. XR_004942960.1 RNA Sequence

    2. XR_004942959.1 RNA Sequence

    3. XR_004942958.1 RNA Sequence

    4. XR_004942961.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153070.1: Suppressed sequence

      Description
      NM_153070.1: This RefSeq was permanently suppressed because it was entirely 3' UTR sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q812A2.1 GenPept UniProtKB/Swiss-Prot:Q812A2

    Gene LinkOut

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