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    KMT2A lysine methyltransferase 2A [ Choloepus didactylus (southern two-toed sloth) ]

    Gene ID: 119538576, updated on 21-Mar-2024

    Summary

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    Gene symbol
    KMT2A
    Gene description
    lysine methyltransferase 2A
    See related
    EnsemblRapid:ENSCDIG00005008778
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Choloepus didactylus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Xenarthra; Pilosa; Folivora; Megalonychidae; Choloepus
    Orthologs
    human mouse all
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    Genomic context

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    See KMT2A in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    100 current mChoDid1.pri (GCF_015220235.1) 6 NC_051312.1 (134329352..134401824)

    Chromosome 6 - NC_051312.1Genomic Context describing neighboring genes Neighboring gene ubiquitination factor E4A Neighboring gene ATP synthase membrane subunit g Neighboring gene uncharacterized LOC119538580 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene transmembrane protein 25

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_051312.1 Chromosome 6 Reference mChoDid1.pri Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone H3K4 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of histone methyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase 2A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Choloepus didactylus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mChoDid1.pri Primary Assembly

    Genomic

    1. NC_051312.1 Reference mChoDid1.pri Primary Assembly

      Range
      134329352..134401824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_037841634.1 → XP_037697562.1  histone-lysine N-methyltransferase 2A isoform X1

      Conserved Domains (9) summary
      cd05493
      Location:1684 → 1814
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3704 → 3787
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1467 → 1513
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1515 → 1564
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1602 → 1661
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1908 → 2020
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1181 → 1228
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3851 → 4004
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2061 → 2108
      FYRN; F/Y-rich N-terminus

    2. XM_037841636.1 → XP_037697564.1  histone-lysine N-methyltransferase 2A isoform X3

      Conserved Domains (9) summary
      cd05493
      Location:1684 → 1814
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3703 → 3786
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1467 → 1513
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1515 → 1564
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1602 → 1661
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1907 → 2019
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1181 → 1228
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3850 → 4003
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2060 → 2107
      FYRN; F/Y-rich N-terminus

    3. XM_037841637.1 → XP_037697565.1  histone-lysine N-methyltransferase 2A isoform X4

      Conserved Domains (9) summary
      cd05493
      Location:1681 → 1811
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3701 → 3784
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1467 → 1513
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1515 → 1564
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1602 → 1658
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1905 → 2017
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1181 → 1228
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3848 → 4001
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2058 → 2105
      FYRN; F/Y-rich N-terminus

    4. XM_037841635.1 → XP_037697563.1  histone-lysine N-methyltransferase 2A isoform X2

      Conserved Domains (9) summary
      cd05493
      Location:1683 → 1813
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3703 → 3786
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1467 → 1513
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1515 → 1563
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1601 → 1660
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1907 → 2019
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1181 → 1228
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3850 → 4003
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2060 → 2107
      FYRN; F/Y-rich N-terminus

    5. XM_037841638.1 → XP_037697566.1  histone-lysine N-methyltransferase 2A isoform X5

      Conserved Domains (9) summary
      cd05493
      Location:1651 → 1781
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3671 → 3754
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1434 → 1480
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1482 → 1531
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1569 → 1628
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1875 → 1987
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1148 → 1195
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3818 → 3971
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2028 → 2075
      FYRN; F/Y-rich N-terminus

    6. XM_037841639.1 → XP_037697567.1  histone-lysine N-methyltransferase 2A isoform X6

      Related
      ENSCDIP00005012238.1, ENSCDIT00005013912.1
      Conserved Domains (9) summary
      cd05493
      Location:1648 → 1778
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:3668 → 3751
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:1434 → 1480
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:1482 → 1531
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:1569 → 1625
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:1872 → 1984
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:1148 → 1195
      zf-CXXC; CXXC zinc finger domain
      cd19170
      Location:3815 → 3968
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
      pfam05964
      Location:2025 → 2072
      FYRN; F/Y-rich N-terminus
    Nucleotide Protein
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