Kpnb1 karyopherin subunit beta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kpnb1provided by RGD
Official Full Name: karyopherin subunit beta 1provided by RGD
Primary source: RGD:2909
See related: EnsemblRapid:ENSRNOG00000009275 AllianceGenome:RGD:2909
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Impnb
Summary: Enables kinesin binding activity. Predicted to be involved in import into nucleus; microtubule cytoskeleton organization; and mitotic sister chromatid segregation. Predicted to act upstream of or within ribosomal protein import into nucleus. Part of nuclear pore. Orthologous to human KPNB1 (karyopherin subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 528.9), Spleen (RPKM 427.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (82642082..82670856, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (82145662..82174437, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (85096517..85124641, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Importin beta, which was locally translated after axotomy, was associated with the dynein-importin alpha complex and was required for axonogenesis.
Title: Axotomy induces axonogenesis in hippocampal neurons by a mechanism dependent on importin β.
In response to acute hyperosmotic challenge, NK3R associates with importin ss-1 which enables the nuclear transport of NK3R.
Title: Expression of the nuclear transport protein importin ß-1 and its association with the neurokinin 3 receptor in the rat hypothalamus following acute hyperosmotic challenge.
data show a differential regulation of imp beta 1 expression after acute and chronic seizure activity in the hippocampus
Title: Seizures increase importin-beta1 expression in NG2+ cells in the rat hippocampus.
PTH1R forms a complex with the transport regulatory proteins, importin alpha(1) and importin beta, and nuclear PTH1R is associated with the nucleoplasm
Title: Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: association of PTH1R with importin alpha1 and beta.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH143721 (e-PCR)
- UniSTS:232967

RH142486 (e-PCR)
- UniSTS:231733

STS-H47054 (e-PCR)
- UniSTS:79462

UniSTS:225255 (e-PCR)
- UniSTS:225255

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IEA Inferred from Electronic Annotation more info
enables Hsp90 protein binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables importin-alpha family protein binding	IEA Inferred from Electronic Annotation more info
enables importin-alpha family protein binding	ISO Inferred from Sequence Orthology more info
enables kinesin binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear import signal receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in NLS-bearing protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in RNA import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in RNA import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in astral microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in astral microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle localization	ISO Inferred from Sequence Orthology more info
involved_in mitotic chromosome movement towards spindle pole	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome movement towards spindle pole	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	IEA Inferred from Electronic Annotation more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosomal protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ribosomal protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in ribosomal protein import into nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NLS-dependent protein nuclear import complex	IEA Inferred from Electronic Annotation more info
part_of NLS-dependent protein nuclear import complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum tubular network	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum tubular network	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: importin subunit beta-1

Names: Importin beta; PTAC97; karyopherin (importin) beta 1; karyopherin,beta 1; nuclear factor P97; pore targeting complex 97 kDa subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017063.2 → NP_058759.2 importin subunit beta-1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P52296

UniProtKB/TrEMBL

F2Z3Q8

Related

ENSRNOP00000012376.3, ENSRNOT00000012376.6

Conserved Domains (2) summary

COG5215
Location:2 → 871

KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]

sd00044
Location:323 → 354

HEAT; HEAT repeat [structural motif]