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    Tspan33 tetraspanin 33 [ Mus musculus (house mouse) ]

    Gene ID: 232670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tspan33provided by MGI
    Official Full Name
    tetraspanin 33provided by MGI
    Primary source
    MGI:MGI:1919012
    See related
    Ensembl:ENSMUSG00000001763 AllianceGenome:MGI:1919012
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pen; 1300010A20Rik
    Summary
    This gene encodes a member of the tetraspanin family which typically have four transmembrane domains. The encoded protein may be involved in the regulation of erythropoiesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
    Expression
    Biased expression in liver E14.5 (RPKM 71.7), liver E14 (RPKM 63.9) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tspan33 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.36 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29694213..29718557)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29694214..29718558)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30896 Neighboring gene predicted gene, 38780 Neighboring gene smoothened, frizzled class receptor Neighboring gene predicted gene 13717 Neighboring gene STARR-positive B cell enhancer ABC_E677 Neighboring gene STARR-seq mESC enhancer starr_15451 Neighboring gene S-adenosylhomocysteine hydrolase-like 2 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29783505-29783805 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29787542-29787842 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29788430-29788731 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847059-29847242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847325-29847478

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling. Ruiz-García A, et al. J Immunol, 2016 Oct 15. PMID 27574297
    2. Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis. Heikens MJ, et al. Blood, 2007 Apr 15. PMID 17158226
    3. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. Haining EJ, et al. J Biol Chem, 2012 Nov 16. PMID 23035126, Free PMC Article
    4. A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity. Shah J, et al. Cell Rep, 2018 Nov 20. PMID 30463011
    5. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggest that TSPAN33 represents a new control element in the development of inflammation by macrophages that could constitute a potential therapeutic target.
      Title: The Tetraspanin TSPAN33 Controls TLR-Triggered Macrophage Activation through Modulation of NOTCH Signaling.
    2. Penumbra has a positive function in erythropoiesis and its deletion or mutation may result in anemia.
      Title: Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC30714

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in pore complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of pore complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of pore complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in tetraspanin-enriched microdomain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetraspanin-33
    Names
    penumbra
    proerythroblast new membrane

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301407.1 → NP_001288336.1  tetraspanin-33 isoform 2

      See identical proteins and their annotated locations for NP_001288336.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC069469, AK004954, BE949216, BF460925, BU054333, CJ068126
      Consensus CDS
      CCDS80506.1
      UniProtKB/Swiss-Prot
      Q8R3S2
      Related
      ENSMUSP00000110905.4, ENSMUST00000115250.4
      Conserved Domains (2) summary
      cd03158
      Location:115 → 235
      penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:22 → 263
      Tetraspannin; Tetraspanin family

    2. NM_146173.3 → NP_666285.1  tetraspanin-33 isoform 1

      See identical proteins and their annotated locations for NP_666285.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC069469, AK004954, BE861472, BE949216, BF460925
      Consensus CDS
      CCDS19964.1
      UniProtKB/Swiss-Prot
      Q3TA03, Q8R3S2
      Related
      ENSMUSP00000045282.8, ENSMUST00000046750.14
      Conserved Domains (2) summary
      cd03158
      Location:116 → 236
      penumbra_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:22 → 264
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      29694213..29718557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3S2.1 GenPept UniProtKB/Swiss-Prot:Q8R3S2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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