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    Tpp2 tripeptidyl peptidase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81815, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tpp2provided by RGD
    Official Full Name
    tripeptidyl peptidase 2provided by RGD
    Primary source
    RGD:621584
    See related
    EnsemblRapid:ENSRNOG00000011194 AllianceGenome:RGD:621584
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TPP-2
    Summary
    Enables peptide binding activity and tripeptidyl-peptidase activity. Involved in protein catabolic process. Predicted to be located in nuclear body. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human TPP2 (tripeptidyl peptidase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 247.0), Spleen (RPKM 243.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tpp2 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (53538788..53620253)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (46046712..46128157)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (50578868..50628943) , (50664048..50744803)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ECRG4 augurin precursor Neighboring gene mitochondrial ribosomal protein L30, pseudogene 7 Neighboring gene U6 spliceosomal RNA Neighboring gene methyltransferase 21C, AARS1 lysine Neighboring gene DnaJ heat shock protein family (Hsp40) member C14, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. [The changes in the activity of tripeptidyl peptidase II in experimental atherosclerosis and hypertension]. Pashevin DO, et al. Fiziol Zh (1994), 2014. PMID 25095668
    2. Tripeptidyl-peptidase II expression and activity are increased in skeletal muscle during sepsis. Wray CJ, et al. Biochem Biophys Res Commun, 2002 Aug 9. PMID 12147224
    3. The structure of human tripeptidyl peptidase II as determined by a hybrid approach. Schönegge AM, et al. Structure, 2012 Apr 4. PMID 22483107
    4. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Rose C, et al. Nature, 1996 Apr 4. PMID 8602240
    5. Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase. Beninga J, et al. J Biol Chem, 1998 Jul 24. PMID 9668046

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Changes in the activity of TPP II play an important role in the pathogenesis of blood vessels wall in atherosclerosis and arterial hypertension.
      Title: [The changes in the activity of tripeptidyl peptidase II in experimental atherosclerosis and hypertension].
    2. increase of expression and activity in skeletal muscle during sepsis
      Title: Tripeptidyl-peptidase II expression and activity are increased in skeletal muscle during sepsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aminopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tripeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tripeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tripeptidyl-peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular amino acid homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tripeptidyl-peptidase 2
    Names
    TPP-II
    tripeptidyl aminopeptidase
    tripeptidyl-peptidase II
    NP_112399.1
    XP_006244914.2
    XP_006244915.2
    XP_063123843.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031137.2 → NP_112399.1  tripeptidyl-peptidase 2

      See identical proteins and their annotated locations for NP_112399.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q64560
      UniProtKB/TrEMBL
      A0A8L2R9L9, A6INR9
      Conserved Domains (2) summary
      cd04857
      Location:14 → 489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam12580
      Location:777 → 963
      TPPII; Tripeptidyl peptidase II

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      53538788..53620253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244852.5 → XP_006244914.2  tripeptidyl-peptidase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8L2R9L9, A6INR8
      Related
      ENSRNOP00000015393.5, ENSRNOT00000015393.7
      Conserved Domains (2) summary
      cd04857
      Location:14 → 489
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam12580
      Location:777 → 963
      TPPII; Tripeptidyl peptidase II

    2. XM_006244853.5 → XP_006244915.2  tripeptidyl-peptidase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2R9L9

    3. XM_063267773.1 → XP_063123843.1  tripeptidyl-peptidase 2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64560.3 GenPept UniProtKB/Swiss-Prot:Q64560

    Gene LinkOut

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