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    Hs3st2 heparan sulfate-glucosamine 3-sulfotransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293451, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hs3st2provided by RGD
    Official Full Name
    heparan sulfate-glucosamine 3-sulfotransferase 2provided by RGD
    Primary source
    RGD:727787
    See related
    EnsemblRapid:ENSRNOG00000017659 AllianceGenome:RGD:727787
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in circadian rhythm. Predicted to be located in Golgi membrane. Human ortholog(s) of this gene implicated in colon cancer; lung cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human HS3ST2 (heparan sulfate-glucosamine 3-sulfotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 25.4) and Heart (RPKM 1.2) See more
    Orthologs
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    Genomic context

    See Hs3st2 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (185387445..185508700)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (175956161..176077400)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (191344979..191474143)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349630 Neighboring gene uncharacterized LOC134483811 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 59 Neighboring gene uncharacterized LOC134483814 Neighboring gene uncharacterized LOC120099923 Neighboring gene ubiquitin specific peptidase 31

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General protein information

    Preferred Names
    heparan sulfate glucosamine 3-O-sulfotransferase 2
    Names
    heparan sulfate (glucosamine) 3-O-sulfotransferase 2
    heparan sulfate 3-O-sulfotransferase 2
    heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2
    NP_852035.1
    XP_063142029.1
    XP_063142034.1
    XP_063142038.1
    XP_063142041.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181370.3NP_852035.1  heparan sulfate glucosamine 3-O-sulfotransferase 2

      See identical proteins and their annotated locations for NP_852035.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      A1A5M1, Q80W66
      UniProtKB/TrEMBL
      A6I8U4
      Related
      ENSRNOP00000023773.5, ENSRNOT00000023773.8
      Conserved Domains (1) summary
      pfam00685
      Location:114351
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      185387445..185508700
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285959.1XP_063142029.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X1

    2. XM_063285964.1XP_063142034.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X2

    3. XM_063285968.1XP_063142038.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X3

    4. XM_063285971.1XP_063142041.1  heparan sulfate glucosamine 3-O-sulfotransferase 2 isoform X4