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    Klf11 KLF transcription factor 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313994, updated on 9-Dec-2024

    Summary

    Official Symbol
    Klf11provided by RGD
    Official Full Name
    KLF transcription factor 11provided by RGD
    Primary source
    RGD:1306646
    See related
    EnsemblRapid:ENSRNOG00000054259 AllianceGenome:RGD:1306646
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tcfcp2l2
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to peptide. Predicted to be located in cytosol; focal adhesion; and nuclear body. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 7 and type 2 diabetes mellitus. Orthologous to human KLF11 (KLF transcription factor 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 80.6), Heart (RPKM 58.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Klf11 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (47014312..47026152)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (41285699..41297548)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (43829812..43841649)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor, RNA polymerase I subunit B Neighboring gene RNA binding motif protein 34, pseudogene 1 Neighboring gene grainyhead-like transcription factor 1 Neighboring gene cystin 1 Neighboring gene ribonucleotide reductase regulatory subunit M2 Neighboring gene uncharacterized LOC120093240

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    Krueppel-like factor 11
    Names
    Kruppel-like factor 11
    transcription factor CP2-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037354.2NP_001032431.2  Krueppel-like factor 11

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      E9PTS6, Q309C9
      Related
      ENSRNOP00000075389.1, ENSRNOT00000086548.3
      Conserved Domains (4) summary
      COG5048
      Location:381438
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:388407
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:443465
      zf-C2H2; Zinc finger, C2H2 type
      cd21584
      Location:40383
      KLF11_N; N-terminal domain of Kruppel-like factor 11

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      47014312..47026152
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239984.5XP_006240046.1  Krueppel-like factor 11 isoform X1

      UniProtKB/TrEMBL
      Q309C9
      Related
      ENSRNOP00000102722.1, ENSRNOT00000157225.1
      Conserved Domains (2) summary
      sd00017
      Location:385407
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:383407
      zf-C2H2; Zinc finger, C2H2 type

    RNA

    1. XR_354724.4 RNA Sequence