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    Glyctk glycerate kinase [ Mus musculus (house mouse) ]

    Gene ID: 235582, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Glyctkprovided by MGI
    Official Full Name
    glycerate kinaseprovided by MGI
    Primary source
    MGI:MGI:2444085
    See related
    Ensembl:ENSMUSG00000020258 AllianceGenome:MGI:2444085
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C430006L12; 6230410P16Rik
    Summary
    Predicted to enable glycerate kinase activity. Involved in fructose catabolic process. Located in mitochondrion. Is expressed in alimentary system; cerebral cortex; liver; and urinary system. Human ortholog(s) of this gene implicated in D-glyceric aciduria. Orthologous to human GLYCTK (glycerate kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver adult (RPKM 79.6), kidney adult (RPKM 48.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Glyctk in Genome Data Viewer
    Location:
    9 F1; 9 57.46 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106030058..106037353, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106152859..106160158, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L6 pseudogene Neighboring gene predicted gene, 51688 Neighboring gene RIKEN cDNA D030055H07 gene Neighboring gene STARR-positive B cell enhancer ABC_E8311 Neighboring gene microRNA 135a-1 Neighboring gene STARR-seq mESC enhancer starr_25138 Neighboring gene STARR-seq mESC enhancer starr_25140 Neighboring gene WD repeat domain containing 82 Neighboring gene microRNA let7g Neighboring gene protein phosphatase 1M

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Untargeted metabolome quantitative trait locus mapping associates variation in urine glycerate to mutant glycerate kinase. Cazier JB, et al. J Proteome Res, 2012 Feb 3. PMID 22029865
    2. d-Glycerate kinase deficiency in a neuropediatric patient. Sass JO, et al. Brain Dev, 2020 Feb. PMID 31837836
    3. Purification of rat liver glycerate kinase and studies of its enzymatic and immunological properties. Katayama H, et al. J Biochem, 1980 Sep. PMID 6252205
    4. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Jang C, et al. Cell Metab, 2018 Feb 6. PMID 29414685, Free PMC Article
    5. Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. Calvo SE, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19372376, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables glycerate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    glycerate kinase
    NP_001034675.1
    NP_777271.3
    XP_006511778.1
    XP_011241181.1
    XP_011241182.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039586.1 → NP_001034675.1  glycerate kinase

      See identical proteins and their annotated locations for NP_001034675.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK049425, AK052709, BB747408, BY111608
      Consensus CDS
      CCDS23469.1
      UniProtKB/Swiss-Prot
      Q7TNX6, Q8BQL0, Q8C717, Q8C7I3, Q8CI81, Q8K0R7, Q8QZY2
      UniProtKB/TrEMBL
      A0A0R4J1H2
      Related
      ENSMUSP00000108162.3, ENSMUST00000112543.9
      Conserved Domains (1) summary
      COG2379
      Location:38 → 515
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

    2. NM_174846.4 → NP_777271.3  glycerate kinase

      See identical proteins and their annotated locations for NP_777271.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK049425, AK052709, BB747408, BY111608
      Consensus CDS
      CCDS23469.1
      UniProtKB/Swiss-Prot
      Q7TNX6, Q8BQL0, Q8C717, Q8C7I3, Q8CI81, Q8K0R7, Q8QZY2
      UniProtKB/TrEMBL
      A0A0R4J1H2
      Related
      ENSMUSP00000047761.7, ENSMUST00000036382.13
      Conserved Domains (1) summary
      COG2379
      Location:38 → 515
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      106030058..106037353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511715.5 → XP_006511778.1  glycerate kinase isoform X1

      See identical proteins and their annotated locations for XP_006511778.1

      UniProtKB/Swiss-Prot
      Q7TNX6, Q8BQL0, Q8C717, Q8C7I3, Q8CI81, Q8K0R7, Q8QZY2
      UniProtKB/TrEMBL
      A0A0R4J1H2
      Conserved Domains (1) summary
      COG2379
      Location:38 → 515
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

    2. XM_011242880.2 → XP_011241182.1  glycerate kinase isoform X1

      See identical proteins and their annotated locations for XP_011241182.1

      UniProtKB/Swiss-Prot
      Q7TNX6, Q8BQL0, Q8C717, Q8C7I3, Q8CI81, Q8K0R7, Q8QZY2
      UniProtKB/TrEMBL
      A0A0R4J1H2
      Conserved Domains (1) summary
      COG2379
      Location:38 → 515
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]

    3. XM_011242879.2 → XP_011241181.1  glycerate kinase isoform X1

      See identical proteins and their annotated locations for XP_011241181.1

      UniProtKB/Swiss-Prot
      Q7TNX6, Q8BQL0, Q8C717, Q8C7I3, Q8CI81, Q8K0R7, Q8QZY2
      UniProtKB/TrEMBL
      A0A0R4J1H2
      Conserved Domains (1) summary
      COG2379
      Location:38 → 515
      GckA; Glycerate-2-kinase [Carbohydrate transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8QZY2.1 GenPept UniProtKB/Swiss-Prot:Q8QZY2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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