U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Apold1 apolipoprotein L domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 444983, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Apold1provided by RGD
    Official Full Name
    apolipoprotein L domain containing 1provided by RGD
    Primary source
    RGD:1303123
    See related
    EnsemblRapid:ENSRNOG00000007830 AllianceGenome:RGD:1303123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Verge
    Summary
    Predicted to enable lipid binding activity. Involved in several processes, including angiogenesis; endothelial cell activation; and regulation of endothelial cell differentiation. Predicted to be located in Weibel-Palade body and cell-cell junction. Orthologous to human APOLD1 (apolipoprotein L domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Apold1 in Genome Data Viewer
    Location:
    4q43
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (169499728..169557075)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (167768437..167825706)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (168752142..168755024)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350781 Neighboring gene G protein-coupled receptor 19 Neighboring gene cyclin-dependent kinase inhibitor 1B Neighboring gene proteasome maturation protein pseudogene Neighboring gene DEAD-box helicase 47 Neighboring gene G protein-coupled receptor, class C, group 5, member A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Verge: a novel vascular early response gene. Regard JB, et al. J Neurosci, 2004 Apr 21. PMID 15102925, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in angiogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in autophagosome-dependent secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagosome-dependent secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in autophagosome-dependent secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endothelial cell activation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipoprotein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of endothelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of endothelial cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of membrane permeability IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane permeability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of membrane permeability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Weibel-Palade body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Weibel-Palade body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Weibel-Palade body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in transport vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    apolipoprotein L domain-containing protein 1
    Names
    vascular early response gene protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003403.2 → NP_001003403.1  apolipoprotein L domain-containing protein 1

      See identical proteins and their annotated locations for NP_001003403.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q6B959
      UniProtKB/TrEMBL
      A6IME9
      Related
      ENSRNOP00000010289.4, ENSRNOT00000010289.6
      Conserved Domains (1) summary
      pfam05461
      Location:69 → 103
      ApoL; Apolipoprotein L

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      169499728..169557075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108001.2 → XP_038963929.1  apolipoprotein L domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G5B0
      Conserved Domains (1) summary
      pfam05461
      Location:74 → 108
      ApoL; Apolipoprotein L

    2. XM_039108003.2 → XP_038963931.1  apolipoprotein L domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G5B0
      Conserved Domains (1) summary
      pfam05461
      Location:74 → 108
      ApoL; Apolipoprotein L

    3. XM_039108004.2 → XP_038963932.1  apolipoprotein L domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G5B0
      Conserved Domains (1) summary
      pfam05461
      Location:74 → 108
      ApoL; Apolipoprotein L

    4. XM_039108005.2 → XP_038963933.1  apolipoprotein L domain-containing protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q6B959
      UniProtKB/TrEMBL
      A6IME9
      Conserved Domains (1) summary
      pfam05461
      Location:69 → 103
      ApoL; Apolipoprotein L

    5. XM_063286435.1 → XP_063142505.1  apolipoprotein L domain-containing protein 1 isoform X2

      Related
      ENSRNOP00000110723.1, ENSRNOT00000158892.1

    6. XM_063286434.1 → XP_063142504.1  apolipoprotein L domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G5B0
      Related
      ENSRNOP00000079429.1, ENSRNOT00000102557.2

    7. XM_039108006.2 → XP_038963934.1  apolipoprotein L domain-containing protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q6B959
      UniProtKB/TrEMBL
      A6IME9
      Related
      ENSRNOP00000109929.1, ENSRNOT00000130334.1
      Conserved Domains (1) summary
      pfam05461
      Location:69 → 103
      ApoL; Apolipoprotein L

    RNA

    1. XR_005503274.2 RNA Sequence

    2. XR_005503268.2 RNA Sequence

    3. XR_010065683.1 RNA Sequence

    4. XR_010065682.1 RNA Sequence

    5. XR_005503271.2 RNA Sequence

    6. XR_005503270.2 RNA Sequence

    7. XR_005503269.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6B959.1 GenPept UniProtKB/Swiss-Prot:Q6B959

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools