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    Olah oleoyl-ACP hydrolase [ Mus musculus (house mouse) ]

    Gene ID: 99035, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Olahprovided by MGI
    Official Full Name
    oleoyl-ACP hydrolaseprovided by MGI
    Primary source
    MGI:MGI:2139018
    See related
    Ensembl:ENSMUSG00000026645 AllianceGenome:MGI:2139018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Thedc1; E230009B14Rik
    Summary
    Predicted to enable fatty acyl-[ACP] hydrolase activity. Predicted to be involved in medium-chain fatty acid biosynthetic process. Predicted to be located in cytosol. Is expressed in ductus deferens; epididymis; prostate gland; and testis. Orthologous to human OLAH (oleoyl-ACP hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Olah in Genome Data Viewer
    Location:
    2 A1; 2 1.88 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3343019..3367964, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3341987..3366569, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene N-myristoyltransferase 2 Neighboring gene predicted gene, 22005 Neighboring gene STARR-positive B cell enhancer ABC_E999 Neighboring gene ribonuclease P/MRP 38 subunit Neighboring gene acyl-Coenzyme A binding domain containing 7 Neighboring gene STARR-seq mESC enhancer starr_03512 Neighboring gene predicted gene, 39750 Neighboring gene STARR-positive B cell enhancer ABC_E5880 Neighboring gene meiosis expressed gene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases. Jia X, et al. Cell, 2024 Aug 22. PMID 39137778
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fatty acyl-[ACP] hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fatty acyl-[ACP] hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in medium-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in medium-chain fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    S-acyl fatty acid synthase thioesterase, medium chain
    Names
    thioesterase II
    thioesterase domain containing 1
    thioesterase domain-containing protein 1
    NP_666033.1
    XP_036018648.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145921.1 → NP_666033.1  S-acyl fatty acid synthase thioesterase, medium chain

      See identical proteins and their annotated locations for NP_666033.1

      Status: VALIDATED

      Source sequence(s)
      BC025001
      Consensus CDS
      CCDS15647.1
      UniProtKB/Swiss-Prot
      Q3UWY0, Q8R197
      Related
      ENSMUSP00000110739.3, ENSMUST00000115087.4
      Conserved Domains (1) summary
      pfam00975
      Location:27 → 242
      Thioesterase; Thioesterase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      3343019..3367964 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162755.1 → XP_036018648.1  S-acyl fatty acid synthase thioesterase, medium chain isoform X1

      UniProtKB/Swiss-Prot
      Q3UWY0, Q8R197
      Related
      ENSMUSP00000027955.5, ENSMUST00000027955.11
      Conserved Domains (1) summary
      pfam00975
      Location:27 → 242
      Thioesterase; Thioesterase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R197.1 GenPept UniProtKB/Swiss-Prot:Q8R197

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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