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    plch2a phospholipase C, eta 2a [ Scyliorhinus canicula (smaller spotted catshark) ]

    Gene ID: 119979762, updated on 21-Mar-2024

    Summary

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    Gene symbol
    plch2a
    Gene description
    phospholipase C, eta 2a
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Scyliorhinus canicula
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae; Scyliorhinus
    Orthologs
    human zebrafish all
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    Genomic context

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    See plch2a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    100 current sScyCan1.1 (GCF_902713615.1) 16 NC_052161.1 (126795354..127107889, complement)

    Chromosome 16 - NC_052161.1Genomic Context describing neighboring genes Neighboring gene pantothenate kinase 4 (inactive) Neighboring gene probable glutamate receptor Neighboring gene S-antigen protein-like Neighboring gene peroxisomal biogenesis factor 10 Neighboring gene retention in endoplasmic reticulum sorting receptor 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_052161.1 Chromosome 16 Reference sScyCan1.1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Scyliorhinus canicula Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference sScyCan1.1 Primary Assembly

    Genomic

    1. NC_052161.1 Reference sScyCan1.1 Primary Assembly

      Range
      126795354..127107889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038822387.1 → XP_038678315.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2a isoform X5

      Conserved Domains (5) summary
      cd00275
      Location:753 → 877
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd13364
      Location:18 → 124
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:142 → 171
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:142 → 282
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl14615
      Location:294 → 723
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    2. XM_038822389.1 → XP_038678317.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2a isoform X6

      Conserved Domains (5) summary
      cd00275
      Location:730 → 854
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd13364
      Location:50 → 156
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:174 → 203
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:174 → 314
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl14615
      Location:326 → 700
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    3. XM_038822384.1 → XP_038678312.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2a isoform X2

      Conserved Domains (5) summary
      cd00275
      Location:783 → 907
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd13364
      Location:50 → 156
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:174 → 203
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:174 → 314
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl14615
      Location:326 → 753
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    4. XM_038822386.1 → XP_038678314.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2a isoform X4

      Conserved Domains (5) summary
      cd00275
      Location:778 → 902
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd13364
      Location:50 → 156
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:174 → 203
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:174 → 314
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl14615
      Location:326 → 755
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    5. XM_038822385.1 → XP_038678313.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2a isoform X3

      Conserved Domains (5) summary
      cd00275
      Location:779 → 903
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd13364
      Location:50 → 156
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:174 → 203
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:174 → 314
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl14615
      Location:326 → 755
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    6. XM_038822383.1 → XP_038678311.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2a isoform X1

      Conserved Domains (5) summary
      cd00275
      Location:785 → 909
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd13364
      Location:50 → 156
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:174 → 203
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:174 → 314
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl14615
      Location:326 → 755
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    7. XM_038822393.1 → XP_038678321.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2a isoform X10

      Conserved Domains (5) summary
      cd00275
      Location:783 → 907
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd13364
      Location:50 → 156
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:174 → 203
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:174 → 314
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl14615
      Location:326 → 753
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    8. XM_038822390.1 → XP_038678318.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2a isoform X7

      Conserved Domains (5) summary
      cd00275
      Location:785 → 909
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd13364
      Location:50 → 156
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:174 → 203
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:174 → 314
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl14615
      Location:326 → 755
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    9. XM_038822391.1 → XP_038678319.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2a isoform X8

      Conserved Domains (5) summary
      cd00275
      Location:785 → 909
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd13364
      Location:50 → 156
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:174 → 203
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:174 → 314
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl14615
      Location:326 → 755
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

    10. XM_038822392.1 → XP_038678320.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2a isoform X9

      Conserved Domains (5) summary
      cd00275
      Location:785 → 909
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd13364
      Location:50 → 156
      PH_PLC_eta; Phospholipase C-eta (PLC-eta) pleckstrin homology (PH) domain
      cd15898
      Location:174 → 203
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:174 → 314
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
      cl14615
      Location:326 → 755
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    Nucleotide Protein
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