Wdr74 WD repeat domain 74 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wdr74provided by MGI
Official Full Name: WD repeat domain 74provided by MGI
Primary source: MGI:MGI:2147427
See related: Ensembl:ENSMUSG00000042729 AllianceGenome:MGI:2147427
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730436H21Rik
Summary: Acts upstream of or within RNA metabolic process and blastocyst formation. Located in nucleus. Is expressed in 8-cell stage embryo; blastocyst; compacted morula; early conceptus; and secondary oocyte. Orthologous to human WDR74 (WD repeat domain 74). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 17.4), liver E14.5 (RPKM 16.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.44 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (8713159..8717988)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (8735795..8740624)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WDR74 facilitates TGF-beta/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice.
Title: WDR74 facilitates TGF-β/Smad pathway activation to promote M2 macrophage polarization and diabetic foot ulcer wound healing in mice.
Wdr74 is required for RNA transcription, processing and/or stability during preimplantation development and is an essential gene in the mouse
Title: Wdr74 is required for blastocyst formation in the mouse.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE457658 (e-PCR)
- UniSTS:209437

Wdr74 (e-PCR), detects polymorphism
- UniSTS:536680

RH124618 (e-PCR)
- UniSTS:161440

RH125702 (e-PCR)
- UniSTS:162471

H31976 (e-PCR)
- UniSTS:261042

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blastocyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of nuclear exosome (RNase complex)	ISO Inferred from Sequence Orthology more info
part_of nuclear exosome (RNase complex)	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
colocalizes_with nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat-containing protein 74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134139.1 → NP_598900.1 WD repeat-containing protein 74

See identical proteins and their annotated locations for NP_598900.1

Status: VALIDATED

Source sequence(s)

BC019968

Consensus CDS

CCDS29541.1

UniProtKB/Swiss-Prot

Q8VCG3

UniProtKB/TrEMBL

Q3UL50

Related

ENSMUSP00000043315.10, ENSMUST00000049424.11

Conserved Domains (3) summary

COG2319
Location:42 → 295

WD40; WD40 repeat [General function prediction only]

sd00039
Location:91 → 127

7WD40; WD40 repeat [structural motif]

cl02567
Location:45 → 302

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

8713159..8717988

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526554.4 → XP_006526617.1 WD repeat-containing protein 74 isoform X1

See identical proteins and their annotated locations for XP_006526617.1

UniProtKB/TrEMBL

Q8R3V4

Conserved Domains (2) summary

sd00039
Location:56 → 90

7WD40; WD40 repeat [structural motif]

cl29593
Location:7 → 167

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...