Atg7 Autophagy-related 7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atg7provided by FlyBase
Official Full Name: Autophagy-related 7provided by FlyBase
Primary source: FLYBASE:FBgn0034366
Locus tag: Dmel_CG5489
See related: AllianceGenome:FB:FBgn0034366
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: atg-7; ATG-7; atg7; ATG7; CG5489; dAtg7; Dmel\CG5489
Summary: Enables Atg8 activating enzyme activity. Involved in several processes, including determination of adult lifespan; larval midgut cell programmed cell death; and positive regulation of autophagy. Predicted to be active in phagophore assembly site. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; salivary gland; and spermatozoon. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 31. Orthologous to human ATG7 (autophagy related 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 55E2-55E2; 2-86 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (18620466..18625044, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (14507971..14512549, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies show that the TOR signaling pathway and ATG5 and ATG7 are crucial for the regulation of cellular processes and can play various functions in different cell types in the brain.
Title: TOR signaling pathway and autophagy are involved in the regulation of circadian rhythms in behavior and plasticity of L2 interneurons in the brain of Drosophila melanogaster.
Fasting increases survival to cold in Atg7 mutant Drosophila melanogaster.
Title: Fasting increases survival to cold in FOXO, DIF, autophagy mutants and in other genotypes of Drosophila melanogaster.
Atg7 acts downstream of Hsp27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila.
Title: Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila.
Atg7 mutant adults are hypersensitive to starvation and oxidative stress, live shorter, and accumulate ubiquitin- positive aggregates in the brain that lead to a progressive decline of neuronal function and cell death.
Title: Drosophila Atg7: required for stress resistance, longevity and neuronal homeostasis, but not for metamorphosis.
Atg7-/- adults are short-lived, hypersensitive to nutrient and oxidative stress, and accumulate ubiquitin-positive aggregates in degenerating neurons.
Title: Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables Atg12 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables Atg12 activating enzyme activity	ISS Inferred from Sequence or Structural Similarity more info
enables Atg8 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables Atg8 activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables Atg8 activating enzyme activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nitrogen starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in piecemeal microautophagy of the nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagy of mitochondrion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification by small protein conjugation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein modification by small protein conjugation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein modification by small protein conjugation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of hemopoiesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
located_in phagophore assembly site	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Autophagy-related 7

Names: Atg7-PA; Atg7-PB; Autophagy-specific gene 7; CG5489-PA; CG5489-PB; autophagy-related gene 7; autophagy-related protein 7

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

18620466..18625044 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166298.3 → NP_725809.1 Autophagy-related 7, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725809.1

Status: REVIEWED

UniProtKB/TrEMBL

A1ZBA9

Related

FBpp0085890

Conserved Domains (2) summary

cd01486
Location:167 → 484

Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...

pfam16420
Location:9 → 68

ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
NM_137506.4 → NP_611350.1 Autophagy-related 7, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611350.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JY94

Related

FBpp0085891

Conserved Domains (3) summary

cd01486
Location:341 → 658

Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...

TIGR01381
Location:11 → 682

E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p

pfam16420
Location:9 → 303

ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus