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    HRH2 histamine receptor H2 [ Canis lupus familiaris (dog) ]

    Gene ID: 403812, updated on 17-Aug-2024

    Summary

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    Official Symbol
    HRH2provided by VGNC
    Official Full Name
    histamine receptor H2provided by VGNC
    Primary source
    VGNC:VGNC:41787
    See related
    Ensembl:ENSCAFG00845000310
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    H2R; HH2R
    Orthologs
    human mouse all
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    Genomic context

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    See HRH2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (37699668..37772370, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (37330979..37332058, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (38272467..38273546, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (37574680..37575759, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (37762745..37763824, complement)

    Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene THO complex subunit 3 Neighboring gene complexin 2 Neighboring gene 40S ribosomal protein S11-like Neighboring gene uncharacterized LOC111095711 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A histamine H₂ receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade. Takahama H, et al. Basic Res Cardiol, 2010 Nov. PMID 20852875
    2. Blockade of histamine H2 receptors protects the heart against ischemia and reperfusion injury in dogs. Asanuma H, et al. J Mol Cell Cardiol, 2006 May. PMID 16603184
    3. Palmitoylation of the canine histamine H2 receptor occurs at Cys(305) and is important for cell surface targeting. Fukushima Y, et al. Biochim Biophys Acta, 2001 Jun 20. PMID 11420116
    4. Molecular cloning of a gene encoding the histamine H2 receptor. Gantz I, et al. Proc Natl Acad Sci U S A, 1991 Jan 15. PMID 1703298, Free PMC Article
    5. Molecular basis for the interaction of histamine with the histamine H2 receptor. Gantz I, et al. J Biol Chem, 1992 Oct 15. PMID 1356984

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Histamine H receptor blockade preserves cardiac systolic function in dogs with pacing-induced heart failure, even in the presence of beta-adrenergic receptor blockade.
      Title: A histamine H₂ receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade.
    2. histamine H(2) receptors have roles in anaerobic myocardial metabolism and in ischemia and reperfusion injury
      Title: Blockade of histamine H2 receptors protects the heart against ischemia and reperfusion injury in dogs.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histamine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neurotransmitter receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in gastric acid secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histamine H2 receptor
    Names
    gastric receptor I
    histamine receptor subtype H2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195844.1 → NP_001182773.1  histamine H2 receptor

      See identical proteins and their annotated locations for NP_001182773.1

      Status: PROVISIONAL

      Source sequence(s)
      JAAUVH010000355
      UniProtKB/Swiss-Prot
      P17124
      UniProtKB/TrEMBL
      A0A8C0KGF2, A0A8C0T527, A0A8I3MAL7
      Conserved Domains (2) summary
      cd14964
      Location:20 → 46
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:19 → 299
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051808.1 Reference ROS_Cfam_1.0

      Range
      37699668..37772370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038662231.1 → XP_038518159.1  histamine H2 receptor isoform X6

      UniProtKB/Swiss-Prot
      P17124
      UniProtKB/TrEMBL
      A0A8C0KGF2, A0A8C0T527, A0A8I3MAL7
      Related
      ENSCAFP00845000340.1, ENSCAFT00845000497.1
      Conserved Domains (2) summary
      cd14964
      Location:20 → 46
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:19 → 299
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_038662225.1 → XP_038518153.1  histamine H2 receptor isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:392 → 535
      PHA03247; large tegument protein UL36; Provisional
      cd15051
      Location:19 → 299
      7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_038662226.1 → XP_038518154.1  histamine H2 receptor isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:392 → 535
      PHA03247; large tegument protein UL36; Provisional
      cd15051
      Location:19 → 299
      7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_038662228.1 → XP_038518156.1  histamine H2 receptor isoform X3

      UniProtKB/TrEMBL
      A0A8C0M1M9, A0A8I3MCA9, A0A8I3MF03, A0A8P0NI50
      Related
      ENSCAFP00845000347.1, ENSCAFT00845000506.1
      Conserved Domains (1) summary
      cd15051
      Location:19 → 299
      7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. XM_038662227.1 → XP_038518155.1  histamine H2 receptor isoform X2

      UniProtKB/TrEMBL
      A0A8C0M8J4, A0A8I3MCA9, A0A8I3MF06, A0A8P0NI50
      Related
      ENSCAFP00845000359.1, ENSCAFT00845000522.1
      Conserved Domains (1) summary
      cd15051
      Location:19 → 299
      7tmA_Histamine_H2R; histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

    6. XM_038662230.1 → XP_038518158.1  histamine H2 receptor isoform X5

      UniProtKB/TrEMBL
      A0A8C0T527, A0A8I3MAL7
      Conserved Domains (2) summary
      cd14964
      Location:20 → 46
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:19 → 299
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    7. XM_038662229.1 → XP_038518157.1  histamine H2 receptor isoform X4

      UniProtKB/TrEMBL
      A0A8C0T527, A0A8I3MAL7
      Conserved Domains (2) summary
      cd14964
      Location:20 → 46
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:19 → 299
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RNA

    1. XR_005425096.1 RNA Sequence

    2. XR_005425097.1 RNA Sequence

    3. XR_005425098.1 RNA Sequence

    4. XR_005425099.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049264.1 Alternate UMICH_Zoey_3.1

      Range
      37574680..37575759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

      Range
      37762745..37763824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

      Range
      38272467..38273546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      37330979..37332058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17124.1 GenPept UniProtKB/Swiss-Prot:P17124

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