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    Whamm WASP homolog associated with actin, golgi membranes and microtubules [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293057, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Whammprovided by RGD
    Official Full Name
    WASP homolog associated with actin, golgi membranes and microtubulesprovided by RGD
    Primary source
    RGD:1563506
    See related
    EnsemblRapid:ENSRNOG00000028113 AllianceGenome:RGD:1563506
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Whdc1; RGD1563506
    Summary
    Predicted to enable Arp2/3 complex binding activity; microtubule binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including Arp2/3 complex-mediated actin nucleation; focal adhesion assembly; and plasma membrane tubulation. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in endoplasmic reticulum-Golgi intermediate compartment membrane. Orthologous to several human genes including WHAMM (WASP homolog associated with actin, golgi membranes and microtubules). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 55.4), Kidney (RPKM 40.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Whamm in Genome Data Viewer
    Location:
    1q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (144935588..144963989)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (135526363..135557091)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (143401986..143430356)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 15 Neighboring gene small nucleolar RNA SNORA76 Neighboring gene fibronectin type III and SPRY domain containing 2 Neighboring gene homer scaffold protein 2 Neighboring gene RNA, U6 small nuclear 946 Neighboring gene RNA guanine-7 methyltransferase activating subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes. Dai A, et al. Nat Commun, 2019 Aug 16. PMID 31420534, Free PMC Article
    2. WHAMM is an Arp2/3 complex activator that binds microtubules and functions in ER to Golgi transport. Campellone KG, et al. Cell, 2008 Jul 11. PMID 18614018, Free PMC Article
    3. RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules. Gad AK, et al. Mol Biol Cell, 2012 Dec. PMID 23087206, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Arp2/3 complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WASP homolog-associated protein with actin, membranes and microtubules
    Names
    WAS protein homolog associated with actin, golgi membranes and microtubules
    WAS protein homology region 2 domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130728.1 → NP_001124200.1  WASP homolog-associated protein with actin, membranes and microtubules

      See identical proteins and their annotated locations for NP_001124200.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473980
      UniProtKB/TrEMBL
      A6JCG9, D3ZKN4
      Related
      ENSRNOP00000060843.2, ENSRNOT00000064667.3
      Conserved Domains (2) summary
      pfam15871
      Location:67 → 435
      JMY; Junction-mediating and -regulatory protein
      pfam15920
      Location:5 → 47
      WHAMM-JMY_N; N-terminal of Junction-mediating and WASP homolog-associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      144935588..144963989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105687.2 → XP_038961615.1  WASP homolog-associated protein with actin, membranes and microtubules isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y913
      Conserved Domains (1) summary
      pfam15871
      Location:1 → 130
      JMY; Junction-mediating and -regulatory protein

    RNA

    1. XR_005501963.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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