eif-2alpha Eukaryotic translation initiation factor 2 subunit 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: eif-2alpha
Official Full Name: Eukaryotic translation initiation factor 2 subunit 1
Primary source: WormBase:WBGene00021351
Locus tag: CELE_Y37E3.10
See related: AllianceGenome:WB:WBGene00021351
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ribosome binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be part of eukaryotic 48S preinitiation complex and eukaryotic translation initiation factor 2 complex. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See eif-2alpha in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (2072680..2076925)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In vivo evidence that stimulation of mRNA translation via eukaryotic initiation factor 2alpha (eIF2alpha) is an essential downstream event of semaphorin signaling in C. elegans.
Title: Semaphorin controls epidermal morphogenesis by stimulating mRNA translation via eIF2alpha in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of eukaryotic 48S preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2 complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Eukaryotic translation initiation factor 2 subunit 1

NP_001368001.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

2072680..2076925

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381335.2 → NP_001368001.1 Eukaryotic translation initiation factor 2 subunit 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q9BKU3

Conserved Domains (1) summary

PTZ00248
Location:3 → 276

PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional