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    aprt-1 Adenine phosphoribosyltransferase;adenine phosphoribosyltransferase [ Caenorhabditis elegans ]

    Gene ID: 172232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aprt-1
    Official Full Name
    Adenine phosphoribosyltransferase;adenine phosphoribosyltransferase
    Primary source
    WormBase:WBGene00020557
    Locus tag
    CELE_T19B4.3
    See related
    AllianceGenome:WB:WBGene00020557
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable AMP binding activity; adenine binding activity; and adenine phosphoribosyltransferase activity. Predicted to be involved in AMP salvage and adenine salvage. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aprt-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (5678638..5679862)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Mitochondrial import inner membrane translocase subunit TIM14 Neighboring gene Netrin receptor unc-40 Neighboring gene RanBP2-type domain-containing protein Neighboring gene putative peptidylglycine alpha-hydroxylating monooxygenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SAFER, an Analysis Method of Quantitative Proteomic Data, Reveals New Interactors of the C. elegans Autophagic Protein LGG-1. Yi Z, et al. J Proteome Res, 2016 May 6. PMID 26999449
    2. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables AMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenine phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in AMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenine salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenine salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine ribonucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Adenine phosphoribosyltransferase;adenine phosphoribosyltransferase
    NP_001407543.1
    • Confirmed by transcript evidence
    NP_491663.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      5678638..5679862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059262.10 → NP_491663.1  Adenine phosphoribosyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491663.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91455
      Conserved Domains (1) summary
      PRK02304
      Location:12 → 183
      PRK02304; adenine phosphoribosyltransferase; Provisional

    2. NM_001420561.1 → NP_001407543.1  adenine phosphoribosyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9J5HXB2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91455.1

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