pab-1 Polyadenylate-binding protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pab-1
Official Full Name: Polyadenylate-binding protein
Primary source: WormBase:WBGene00003902
Locus tag: CELE_Y106G6H.2
See related: AllianceGenome:WB:WBGene00003902
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables mRNA binding activity. Involved in several processes, including establishment of mitotic spindle localization; positive regulation of vulval development; and regulation of cell cycle process. Located in P granule and P-body. Is expressed in intestine and neurons. Orthologous to several human genes including PABPC1 (poly(A) binding protein cytoplasmic 1); PABPC1L (poly(A) binding protein cytoplasmic 1 like); and PABPC3 (poly(A) binding protein cytoplasmic 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pab-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 6

Sequence:: Chromosome: I; NC_003279.8 (10432861..10435238, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It was found that C. elegans PAB1 and PAB2 are required for miRNA-mediated silencing in embryonic and larval developmental stages, where they act through a multi-faceted mechanism.
Title: Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans.
Two different mutations on the same gene, pab-1, which encodes a poly(A)-binding protein show defect in germline stem cell proliferation.
Title: Two mutations in pab-1 encoding poly(A)-binding protein show similar defects in germline stem cell proliferation but different longevity in C. elegans.
PAB-1, a Caenorhabditis elegans poly(A)-binding protein, regulates mRNA metabolism in germline by interacting with CGH-1 and CAR-1.
Title: PAB-1, a Caenorhabditis elegans poly(A)-binding protein, regulates mRNA metabolism in germline by interacting with CGH-1 and CAR-1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y106G6H.4 (e-PCR)
- UniSTS:321089

Y106G6H.3 (e-PCR)
- UniSTS:322447

Y106G6H.2 (e-PCR)
- UniSTS:312977

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(A) binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly(U) RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in establishment of mitotic spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of germ cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle, embryonic	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitotic cytokinetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of spindle assembly	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Polyadenylate-binding protein

NP_001369814.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10432861..10435238 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383718.2 → NP_001369814.1 Polyadenylate-binding protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q17350, Q9U302

Conserved Domains (1) summary

TIGR01628
Location:32 → 640

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family