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    bpl-1 BPL/LPL catalytic domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174039, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bpl-1
    Official Full Name
    BPL/LPL catalytic domain-containing protein
    Primary source
    WormBase:WBGene00000259
    Locus tag
    CELE_F13H8.10
    See related
    AllianceGenome:WB:WBGene00000259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable biotin--[biotin carboxyl-carrier protein] ligase activity. Predicted to be involved in protein modification process. Predicted to be active in cytoplasm. Is expressed in Psub1. Human ortholog(s) of this gene implicated in holocarboxylase synthetase deficiency. Orthologous to human HLCS (holocarboxylase synthetase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bpl-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    19
    Sequence:
    Chromosome: II; NC_003280.10 (6274216..6279699)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Small-subunit processome Utp12 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Selenocysteine lyase Neighboring gene Enhancer of polycomb-like protein Neighboring gene DUF4238 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The biotin-ligating protein BPL-1 is critical for lipid biosynthesis and polarization of the Caenorhabditis elegans embryo. Watts JS, et al. J Biol Chem, 2018 Jan 12. PMID 29158261, Free PMC Article
    2. Asymmetric transcript discovery by RNA-seq in C. elegans blastomeres identifies neg-1, a gene important for anterior morphogenesis. Osborne Nishimura E, et al. PLoS Genet, 2015 Apr. PMID 25875092, Free PMC Article
    3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    4. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables biotin--[biotin carboxyl-carrier protein] ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables biotin--[biotin carboxyl-carrier protein] ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BPL/LPL catalytic domain-containing protein
    NP_001379739.1
    • Confirmed by transcript evidence
    NP_495257.3
    • Confirmed by transcript evidence
    NP_871920.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6274216..6279699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062856.8 → NP_495257.3  BPL/LPL catalytic domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495257.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BI98
      Conserved Domains (1) summary
      cd16442
      Location:964 → 1136
      BPL; biotin protein ligase

    2. NM_182120.6 → NP_871920.1  BPL/LPL catalytic domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871920.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECZ9
      Conserved Domains (1) summary
      cd16442
      Location:381 → 553
      BPL; biotin protein ligase

    3. NM_001393097.1 → NP_001379739.1  BPL/LPL catalytic domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFB4
      Conserved Domains (1) summary
      cd16442
      Location:307 → 479
      BPL; biotin protein ligase
    Nucleotide Protein
    Heading Accession and Version

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