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    eif-3.G Eukaryotic translation initiation factor 3 subunit G [ Caenorhabditis elegans ]

    Gene ID: 174346, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eif-3.G
    Official Full Name
    Eukaryotic translation initiation factor 3 subunit G
    Primary source
    WormBase:WBGene00001230
    Locus tag
    CELE_F22B5.2
    See related
    AllianceGenome:WB:WBGene00001230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables mRNA 5'-UTR binding activity. Involved in positive regulation of translation. Located in cytoplasm. Is expressed in germ line and somatic cell. Orthologous to human EIF3G (eukaryotic translation initiation factor 3 subunit G). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eif-3.G in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (8442767..8444175)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ACid Phosphatase family Neighboring gene LIPaSe related Neighboring gene ADP-ribosylation factor-like protein 2 Neighboring gene Cuticlin-3 Neighboring gene Mitochondrial cytochrome c oxidase subunit VIa Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans LIN-66 mediates EIF-3/eIF3-dependent protein translation via a cold-shock domain. Blazie SM, et al. Life Sci Alliance, 2024 Sep. PMID 38886018, Free PMC Article
    2. Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity. Blazie SM, et al. Elife, 2021 Jul 29. PMID 34323215, Free PMC Article
    3. Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Kamath RS, et al. Nature, 2003 Jan 16. PMID 12529635
    4. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.
      Title: Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Eukaryotic translation initiation factor 3 subunit G
    NP_001263666.1
    • Confirmed by transcript evidence
    NP_495778.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8442767..8444175
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276737.3 → NP_001263666.1  Eukaryotic translation initiation factor 3 subunit G [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263666.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      K8ESE1, Q19706
      Conserved Domains (3) summary
      COG0724
      Location:176 → 260
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12933
      Location:33 → 143
      eIF3G; eIF3G domain found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins
      cd12408
      Location:183 → 259
      RRM_eIF3G_like; RNA recognition motif in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins

    2. NM_063377.5 → NP_495778.1  Eukaryotic translation initiation factor 3 subunit G [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495778.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19706
      Conserved Domains (3) summary
      COG0724
      Location:170 → 254
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12933
      Location:27 → 137
      eIF3G; eIF3G domain found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins
      cd12408
      Location:177 → 253
      RRM_eIF3G_like; RNA recognition motif in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19706.2

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