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    mnk-1 MAP kinase-interacting serine/threonine-protein kinase mnk-1 [ Caenorhabditis elegans ]

    Gene ID: 174623, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mnk-1
    Official Full Name
    MAP kinase-interacting serine/threonine-protein kinase mnk-1
    Primary source
    WormBase:WBGene00011304
    Locus tag
    CELE_R166.5
    See related
    AllianceGenome:WB:WBGene00011304
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium-dependent protein serine/threonine kinase activity; calcium/calmodulin-dependent protein kinase activity; and calmodulin binding activity. Involved in behavioral response to nicotine; determination of adult lifespan; and regulation of protein deneddylation. Located in nucleus. Is expressed in body wall musculature; intestine; pharynx; and vulval muscle. Orthologous to several human genes including MKNK2 (MAPK interacting serine/threonine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mnk-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (10542421..10555044, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Pre-rRNA-processing protein pro-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle. Matsunaga Y, et al. Mol Biol Cell, 2015 Jun 1. PMID 25851606, Free PMC Article
    2. eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Syntichaki P, et al. Nature, 2007 Feb 22. PMID 17277769
    3. SAMS-1 coordinates HLH-30/TFEB and PHA-4/FOXA activities through histone methylation to mediate dietary restriction-induced autophagy and longevity. Lim CY, et al. Autophagy, 2023 Jan. PMID 35503435, Free PMC Article
    4. Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1. Dorfman M, et al. Genetics, 2009 Aug. PMID 19528325, Free PMC Article
    5. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in behavioral response to nicotine IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in behavioral response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein deneddylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MAP kinase-interacting serine/threonine-protein kinase mnk-1
    NP_496272.2
    • Confirmed by transcript evidence
    NP_871924.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10542421..10555044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063871.6 → NP_496272.2  MAP kinase-interacting serine/threonine-protein kinase mnk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496272.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I113
      Conserved Domains (2) summary
      smart00220
      Location:205 → 491
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:198 → 490
      PKc_like; Protein Kinases, catalytic domain

    2. NM_182124.8 → NP_871924.2  MAP kinase-interacting serine/threonine-protein kinase mnk-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871924.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22005, Q8I113
      Conserved Domains (1) summary
      cl21453
      Location:200 → 492
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I113.2

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