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    tag-180 VWFA domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174730, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tag-180
    Official Full Name
    VWFA domain-containing protein
    Primary source
    WormBase:WBGene00007041
    Locus tag
    CELE_T24F1.6
    See related
    AllianceGenome:WB:WBGene00007041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in head neurons; intestine; and tail neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 110. Orthologous to human CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1) and CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tag-180 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    19
    Sequence:
    Chromosome: II; NC_003280.10 (11323047..11329429, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene EGF-like domain-containing protein Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene tRNA-Ala Neighboring gene ncRNA Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegans mechanosensory neurons. Frøkjaer-Jensen C, et al. J Neurobiol, 2006 Sep 1. PMID 16838374
    2. The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology. Caylor RC, et al. Neural Dev, 2013 May 10. PMID 23663262, Free PMC Article
    3. The alpha1 subunit EGL-19, the alpha2/delta subunit UNC-36, and the beta subunit CCB-1 underlie voltage-dependent calcium currents in Caenorhabditis elegans striated muscle. Lainé V, et al. J Biol Chem, 2011 Oct 21. PMID 21878625, Free PMC Article
    4. Distinct Neural Circuits Control Rhythm Inhibition and Spitting by the Myogenic Pharynx of C. elegans. Bhatla N, et al. Curr Biol, 2015 Aug 17. PMID 26212880, Free PMC Article
    5. Nicotine Motivated Behavior in C. elegans. Salim C, et al. Int J Mol Sci, 2024 Jan 29. PMID 38338915, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    VWFA domain-containing protein
    NP_001022363.1
    • Confirmed by transcript evidence
    NP_001022364.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11323047..11329429 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027193.5 → NP_001022364.1  VWFA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022364.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG74
      Conserved Domains (3) summary
      cd01463
      Location:220 → 411
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam08399
      Location:106 → 201
      VWA_N; VWA N-terminal
      pfam02743
      Location:430 → 517
      dCache_1; Cache domain

    2. NM_001027192.6 → NP_001022363.1  VWFA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022363.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGL3
      Conserved Domains (3) summary
      cd01463
      Location:220 → 411
      vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...
      pfam08399
      Location:106 → 201
      VWA_N; VWA N-terminal
      pfam02743
      Location:430 → 517
      dCache_1; Cache domain
    Nucleotide Protein
    Heading Accession and Version

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