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    disl-2 DIS3-like exonuclease 2 [ Caenorhabditis elegans ]

    Gene ID: 175748, updated on 9-Dec-2024

    Summary

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    Official Symbol
    disl-2
    Official Full Name
    DIS3-like exonuclease 2
    Primary source
    WormBase:WBGene00018612
    Locus tag
    CELE_F48E8.6
    See related
    AllianceGenome:WB:WBGene00018612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 3'-5'-RNA exonuclease activity. Involved in regulation of cell fate specification and regulation of development, heterochronic. Predicted to be located in cytoplasm. Predicted to be active in P-body. Human ortholog(s) of this gene implicated in Perlman syndrome and nephroblastoma. Orthologous to human DIS3L2 (DIS3 like 3'-5' exoribonuclease 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See disl-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (5443167..5446506)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene NET domain-containing protein;Protein kinase domain-containing protein Neighboring gene DM2 domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene Hsp20/alpha crystallin family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RdRP-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway. Zhou X, et al. Nat Struct Mol Biol, 2017 Mar. PMID 28165511
    2. CDE-1 suppresses the production of risiRNA by coupling polyuridylation and degradation of rRNA. Wang Y, et al. BMC Biol, 2020 Sep 4. PMID 32887607, Free PMC Article
    3. RNA surveillance is required for endoplasmic reticulum homeostasis. Sakaki K, et al. Proc Natl Acad Sci U S A, 2012 May 22. PMID 22562797, Free PMC Article
    4. Interaction between quality control systems for ER protein folding and RNA biogenesis. Sakaki K, et al. Worm, 2013 Apr 1. PMID 24058870, Free PMC Article
    5. CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans. Weaver BP, et al. Elife, 2014 Dec 30. PMID 25432023, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5'-RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in miRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyuridylation-dependent mRNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of development, heterochronic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DIS3-like exonuclease 2
    NP_498160.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5443167..5446506
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065759.7 → NP_498160.2  DIS3-like exonuclease 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498160.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09568
      Conserved Domains (2) summary
      COG0557
      Location:76 → 770
      VacB; Exoribonuclease R [Transcription]
      pfam00773
      Location:333 → 685
      RNB; RNB domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09568.2

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