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    tyr-1 Putative tyrosinase-like protein tyr-1 [ Caenorhabditis elegans ]

    Gene ID: 176105, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tyr-1
    Official Full Name
    Putative tyrosinase-like protein tyr-1
    Primary source
    WormBase:WBGene00015332
    Locus tag
    CELE_C02C2.1
    See related
    AllianceGenome:WB:WBGene00015332
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity and monooxygenase activity. Human ortholog(s) of this gene implicated in several diseases, including melanoma (multiple); ocular albinism 1; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to several human genes including DCT (dopachrome tautomerase) and TYR (tyrosinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tyr-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (7873781..7877194)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative transporter slc-17.3 Neighboring gene Acetylcholine receptor-like protein cup-4 Neighboring gene Iodotyrosine dehalogenase 1 homolog Neighboring gene TIP41-like protein Neighboring gene Transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights into the evolution of metazoan tyrosinase gene family. Esposito R, et al. PLoS One, 2012. PMID 22536431, Free PMC Article
    2. Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress. Egge N, et al. Nat Commun, 2021 Mar 5. PMID 33674585, Free PMC Article
    3. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
    4. Protein interaction mapping in C. elegans using proteins involved in vulval development. Walhout AJ, et al. Science, 2000 Jan 7. PMID 10615043
    5. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Putative tyrosinase-like protein tyr-1
    NP_498711.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7873781..7877194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066310.7 → NP_498711.1  Putative tyrosinase-like protein tyr-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498711.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34269, P34270
      Conserved Domains (2) summary
      smart00254
      Location:523 → 557
      ShKT; ShK toxin domain
      pfam00264
      Location:141 → 328
      Tyrosinase; Common central domain of tyrosinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34269.2

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