pmk-3 Mitogen-activated protein kinase pmk-3;Protein kinase domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pmk-3
Official Full Name: Mitogen-activated protein kinase pmk-3;Protein kinase domain-containing protein
Primary source: WormBase:WBGene00004057
Locus tag: CELE_F42G8.4
See related: AllianceGenome:WB:WBGene00004057
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including behavioral response to nicotine; p38MAPK cascade; and regulation of axon extension. Located in cytoplasm and nucleus. Is expressed in several structures, including gonad and intestine. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pmk-3 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (8139219..8143151)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons.
Title: Alleviating chronic ER stress by p38-Ire1-Xbp1 pathway and insulin-associated autophagy in C. elegans neurons.
The p38MAPK/ATF-7 immune pathway is triggered by mitochondrial complex I dysfunction.
Title: The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective.
ribosomal inactivation-induced iron accumulation in Caenorhabditis elegans as a simplified in vivo model for gut nutrition uptake was dependent on SEK-1, a p38 kinase activator, leading to suppression of FPN-1.1 expression and iron accumulation.
Title: Non-mutagenic Suppression of Enterocyte Ferroportin 1 by Chemical Ribosomal Inactivation via p38 Mitogen-activated Protein Kinase (MAPK)-mediated Regulation: EVIDENCE FOR ENVIRONMENTAL HEMOCHROMATOSIS.
cytosol-localized HSP-60 physically binds and stabilizes SEK-1/MAP kinase kinase 3, which in turn up-regulates p38 MAP kinase and increases immunity.
Title: Mitochondrial chaperone HSP-60 regulates anti-bacterial immunity via p38 MAP kinase signaling.
DLK-1, SEK-3 and PMK-3 have roles in C. elegans adaptation to disruption of the mitochondrial electron transport chain, and in extended lifespan
Title: DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans.
Mutants lacking p38 MAPK components pmk-1 or sek-1 resemble mutants lacking the hypoxia response component and prolyl hydroxylase egl-9, with impaired subcellular localization of Mint orthologue LIN-10, internalization of glutamate receptor GLR-1, and depression of GLR-1-mediated behaviors.
Title: The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons.
ROS generation by Ce-Duox1/BLI-3 activates a protective SKN-1 response via p38 MAPK signaling.
Title: Ce-Duox1/BLI-3 generated reactive oxygen species trigger protective SKN-1 activity via p38 MAPK signaling during infection in C. elegans.
RPM-1 and PMK-3/p38 MAPK have roles in regulating the endosomal trafficking of AMPARs at central synapses
Title: The ubiquitin ligase RPM-1 and the p38 MAPK PMK-3 regulate AMPA receptor trafficking.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F42G8.4 (e-PCR)
- UniSTS:310289

F42G8.5 (e-PCR)
- UniSTS:310290

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in behavioral response to nicotine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension involved in regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of 3'-UTR-mediated mRNA stabilization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of axon extension involved in axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synapse organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mitogen-activated protein kinase pmk-3;Protein kinase domain-containing protein

NP_001294205.1

Confirmed by transcript evidence

NP_001379550.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8139219..8143151

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392343.1 → NP_001379550.1 Mitogen-activated protein kinase pmk-3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O44514

Conserved Domains (1) summary

cd07851
Location:102 → 461

STKc_p38; Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase
NM_001307276.3 → NP_001294205.1 Protein kinase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294205.1

Status: REVIEWED

UniProtKB/TrEMBL

W6RTQ3

Conserved Domains (1) summary

cl21453
Location:1 → 287

PKc_like; Protein Kinases, catalytic domain