gta-1 putative 4-aminobutyrate aminotransferase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gta-1
Official Full Name: putative 4-aminobutyrate aminotransferase, mitochondrial
Primary source: WormBase:WBGene00001794
Locus tag: CELE_K04D7.3
See related: AllianceGenome:WB:WBGene00001794
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable pyridoxal phosphate binding activity. Predicted to be involved in gamma-aminobutyric acid catabolic process. Located in mitochondrion. Is expressed in body wall musculature and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gta-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (10180660..10183865)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K04D7.3 (e-PCR)
- UniSTS:321557

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables (S)-3-amino-2-methylpropionate transaminase activity	IEA Inferred from Electronic Annotation more info
enables 4-aminobutyrate:2-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in gamma-aminobutyric acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative 4-aminobutyrate aminotransferase, mitochondrial

NP_001294091.1

Confirmed by transcript evidence

NP_501862.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10180660..10183865

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069461.5 → NP_501862.1 putative 4-aminobutyrate aminotransferase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501862.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21217

Conserved Domains (2) summary

COG0160
Location:23 → 483

GabT; 4-aminobutyrate aminotransferase or related aminotransferase [Amino acid transport and metabolism]

cl18945
Location:24 → 480

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
NM_001307162.3 → NP_001294091.1 putative 4-aminobutyrate aminotransferase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294091.1

Status: REVIEWED

UniProtKB/TrEMBL

N1NVC4

Conserved Domains (1) summary

cl18945
Location:1 → 336

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...