F11E6.8 Protein kinase domain-containing protein;Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F11E6.8
Official Full Name: Protein kinase domain-containing protein;Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein
Primary source: WormBase:WBGene00008711
Locus tag: CELE_F11E6.8
See related: AllianceGenome:WB:WBGene00008711
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in cell migration; cell surface receptor protein tyrosine kinase signaling pathway; and nervous system development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); distal arthrogryposis; and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase) and MST1R (macrophage stimulating 1 receptor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See F11E6.8 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 12

Sequence:: Chromosome: IV; NC_003282.8 (17444120..17450543, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

F11E6.8 (e-PCR)
- UniSTS:306918

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Protein kinase domain-containing protein;Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein

NP_001255960.1

Confirmed by transcript evidence

NP_001255961.2

Confirmed by transcript evidence

NP_001255962.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

17444120..17450543 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001269032.3 → NP_001255961.2 Protein kinase domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

C0P284

Conserved Domains (1) summary

cd00192
Location:84 → 343

PTKc; Catalytic domain of Protein Tyrosine Kinases
NM_001269031.4 → NP_001255960.1 Protein kinase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255960.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XVQ7

Conserved Domains (1) summary

cd00192
Location:141 → 400

PTKc; Catalytic domain of Protein Tyrosine Kinases
NM_001269033.3 → NP_001255962.1 Serine-threonine/tyrosine-protein kinase catalytic domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255962.1

Status: REVIEWED

UniProtKB/TrEMBL

F1LIN3

Conserved Domains (1) summary

cl21453
Location:1 → 66

PKc_like; Protein Kinases, catalytic domain