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    smg-4 UPF3 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179371, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smg-4
    Official Full Name
    UPF3 domain-containing protein
    Primary source
    WormBase:WBGene00004882
    Locus tag
    CELE_F46B6.3
    See related
    AllianceGenome:WB:WBGene00004882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Involved in male genitalia development and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in nucleus and perinuclear region of cytoplasm. Is expressed in intestinal cell; muscle cell; and neurons. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 14. Orthologous to human UPF3A (UPF3A regulator of nonsense mediated mRNA decay) and UPF3B (UPF3B regulator of nonsense mediated mRNA decay). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smg-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (9775935..9777745, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Homeobox protein unc-42 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene UPF0587 protein F46B6.12 Neighboring gene Hflx-type G domain-containing protein Neighboring gene LisH domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular identification of smg-4, required for mRNA surveillance in C. elegans. Aronoff R, et al. Gene, 2001 May 2. PMID 11368911
    2. Suppressors of the unc-73 gene of Caenorhabditis elegans. Run JQ, et al. Genetics, 1996 May. PMID 8722777, Free PMC Article
    3. SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans. Grimson A, et al. Mol Cell Biol, 2004 Sep. PMID 15314158, Free PMC Article
    4. smg mutants affect the expression of alternatively spliced SR protein mRNAs in Caenorhabditis elegans. Morrison M, et al. Proc Natl Acad Sci U S A, 1997 Sep 2. PMID 9275202, Free PMC Article
    5. RNA surveillance is required for endoplasmic reticulum homeostasis. Sakaki K, et al. Proc Natl Acad Sci U S A, 2012 May 22. PMID 22562797, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UPF3 domain-containing protein
    NP_741600.1
    • Confirmed by transcript evidence
    NP_741601.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9775935..9777745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171514.6 → NP_741600.1  UPF3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741600.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQF3
      Conserved Domains (2) summary
      pfam03467
      Location:9 → 171
      Smg4_UPF3; Smg-4/UPF3 family
      pfam15677
      Location:282 → 362
      CEND1; Cell cycle exit and neuronal differentiation protein 1

    2. NM_171515.6 → NP_741601.1  UPF3 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741601.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20445
      Conserved Domains (1) summary
      pfam03467
      Location:9 → 171
      Smg4_UPF3; Smg-4/UPF3 family
    Nucleotide Protein
    Heading Accession and Version

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