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    gsp-1 Serine/threonine-protein phosphatase PP1-alpha [ Caenorhabditis elegans ]

    Gene ID: 179486, updated on 4-Jan-2025

    Summary

    Official Symbol
    gsp-1
    Official Full Name
    Serine/threonine-protein phosphatase PP1-alpha
    Primary source
    WormBase:WBGene00001747
    Locus tag
    CELE_F29F11.6
    See related
    AllianceGenome:WB:WBGene00001747
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Involved in negative regulation of protein phosphorylation and positive regulation of gene expression. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including anal sphincter muscle; excretory cell; nervous system; oocyte; and reproductive system. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See gsp-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (10682422..10686537)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity  
    enables metal ion binding  
    enables myosin phosphatase activity  
    enables phosphoprotein phosphatase activity  
    enables protein binding PubMed 
    enables protein serine/threonine phosphatase activity  
    enables protein serine/threonine phosphatase activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in nucleus  

    General protein information

    Preferred Names
    Serine/threonine-protein phosphatase PP1-alpha
    NP_001256250.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10682422..10686537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269321.4 → NP_001256250.1  Serine/threonine-protein phosphatase PP1-alpha [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256250.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q27497
      Conserved Domains (1) summary
      cd07414
      Location:8 → 298
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
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