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    ceh-32 Homeobox protein ceh-32 [ Caenorhabditis elegans ]

    Gene ID: 179603, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ceh-32
    Official Full Name
    Homeobox protein ceh-32
    Primary source
    WormBase:WBGene00000453
    Locus tag
    CELE_W05E10.3
    See related
    AllianceGenome:WB:WBGene00000453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and post-embryonic animal morphogenesis. Located in nucleus. Is expressed in several structures, including anterior hypodermis; gonadal sheath cell; head ganglion; pharyngeal neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in holoprosencephaly; holoprosencephaly 2; optic disc anomalies with retinal and/or macular dystrophy; and renal Wilms' tumor. Orthologous to several human genes including SIX3 (SIX homeobox 3) and SIX6 (SIX homeobox 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ceh-32 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (11701764..11705400, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lineage context switches the function of a C. elegans Pax6 homolog in determining a neuronal fate. Brandt JP, et al. Development, 2019 Apr 15. PMID 30890567, Free PMC Article
    2. Insight into transcription factor gene duplication from Caenorhabditis elegans Promoterome-driven expression patterns. Reece-Hoyes JS, et al. BMC Genomics, 2007 Jan 23. PMID 17244357, Free PMC Article
    3. The Caenorhabditis elegans Six/sine oculis class homeobox gene ceh-32 is required for head morphogenesis. Dozier C, et al. Dev Biol, 2001 Aug 15. PMID 11476572
    4. Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development. Yanagi K, et al. J Biol Chem, 2005 May 20. PMID 15811859
    5. A conserved Six-Eya cassette acts downstream of Wnt signaling to direct non-myogenic versus myogenic fates in the C. elegans postembryonic mesoderm. Amin NM, et al. Dev Biol, 2009 Jul 15. PMID 19427847, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic animal morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox protein ceh-32
    NP_505958.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11701764..11705400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073557.7 → NP_505958.1  Homeobox protein ceh-32 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q23175, Q9BMH2
      Conserved Domains (2) summary
      cd00086
      Location:187 → 236
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam16878
      Location:68 → 179
      SIX1_SD; Transcriptional regulator, SIX1, N-terminal SD domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23175.2

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