skr-3 Skp1-related protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: skr-3
Official Full Name: Skp1-related protein
Primary source: WormBase:WBGene00004809
Locus tag: CELE_F44G3.6
See related: AllianceGenome:WB:WBGene00004809
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cullin family protein binding activity. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine and pharynx. Orthologous to human SKP1 (S-phase kinase associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See skr-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 3

Sequence:: Chromosome: V; NC_003283.11 (16121824..16122648)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F44G3.6 (e-PCR)
- UniSTS:315779

STS5-234 (e-PCR)
- UniSTS:242399

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	HEP more info	PubMed
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Skp1-related protein

NP_507059.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

16121824..16122648

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074658.7 → NP_507059.1 Skp1-related protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507059.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EE67

Conserved Domains (3) summary

smart00512
Location:7 → 117

Skp1; Found in Skp1 protein family

COG5201
Location:10 → 167

SKP1; SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]

pfam01466
Location:91 → 165

Skp1; Skp1 family, dimerization domain