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    asns-2 Asparagine synthetase [glutamine-hydrolyzing] [ Caenorhabditis elegans ]

    Gene ID: 181121, updated on 9-Dec-2024

    Summary

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    Official Symbol
    asns-2
    Official Full Name
    Asparagine synthetase [glutamine-hydrolyzing]
    Primary source
    WormBase:WBGene00019730
    Locus tag
    CELE_M02D8.4
    See related
    AllianceGenome:WB:WBGene00019730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable asparagine synthase (glutamine-hydrolyzing) activity. Predicted to be involved in asparagine biosynthetic process. Predicted to be active in cytosol. Is expressed in intestine. Orthologous to human ASNS (asparagine synthetase (glutamine-hydrolyzing)). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See asns-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (8748434..8750941, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene WW domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene CUB_2 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Modulation of Neurotransmitter Pathways and Associated Metabolites by Systemic Silencing of Gut Genes in C. elegans. Shukla S, et al. Diagnostics (Basel), 2023 Jul 10. PMID 37510066, Free PMC Article
    2. Caenorhabditis elegans HCF-1 functions in longevity maintenance as a DAF-16 regulator. Li J, et al. PLoS Biol, 2008 Sep 30. PMID 18828672, Free PMC Article
    3. Stable-isotope labeling with amino acids in nematodes. Larance M, et al. Nat Methods, 2011 Aug 28. PMID 21874007, Free PMC Article
    4. Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans. Feng D, et al. PLoS One, 2024. PMID 38517909, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables asparagine synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables asparagine synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-asparagine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asparagine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in asparagine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Asparagine synthetase [glutamine-hydrolyzing]
    NP_741864.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8748434..8750941 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171746.6 → NP_741864.1  Asparagine synthetase [glutamine-hydrolyzing] [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741864.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21463
      Conserved Domains (1) summary
      PRK09431
      Location:1 → 538
      asnB; asparagine synthetase B; Provisional
    Nucleotide Protein
    Heading Accession and Version

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