U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Sec14l3 SEC14-like lipid binding 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64543, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sec14l3provided by RGD
    Official Full Name
    SEC14-like lipid binding 3provided by RGD
    Primary source
    RGD:620812
    See related
    EnsemblRapid:ENSRNOG00000004555 AllianceGenome:RGD:620812
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spf2
    Summary
    Predicted to enable lipid binding activity. Predicted to be active in cytoplasm. Orthologous to human SEC14L3 (SEC14 like lipid binding 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 2450.0) See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sec14l3 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (83168154..83181240)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78944568..78955608)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (84306466..84317241)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096646 Neighboring gene ribosomal protein L9, pseudogene 25 Neighboring gene uncharacterized LOC102549281 Neighboring gene mitochondrial fission process 1 Neighboring gene SEC14-like lipid binding 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Inverse relationship between Sec14l3 mRNA/protein expression and allergic airway inflammation. Shan L, et al. Eur J Pharmacol, 2009 Aug 15. PMID 19577556
    2. Secretion of the mammalian Sec14p-like phosphoinositide-binding p45 protein. Merkulova M, et al. FEBS J, 2005 Nov. PMID 16262698
    3. A novel 45 kDa secretory protein from rat olfactory epithelium: primary structure and localisation. Merkulova MI, et al. FEBS Lett, 1999 Apr 30. PMID 10350070
    4. Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A. Mokashi V, et al. Biochem Biophys Res Commun, 2004 Apr 9. PMID 15033454
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SPF2 (supernatant protein factor-like protein), appears to be predominantly expressed in respiratory and epithelial tissues.
      Title: Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A.
    2. Sec14p-like phosphoinositide-binding p45 protein and phosphoinositides may participate in the formation of the protective mucus on nasal epithelium.
      Title: Secretion of the mammalian Sec14p-like phosphoinositide-binding p45 protein.
    3. Sec14l3 expression is highly and inversely associated with the progression of airway inflammation.
      Title: Inverse relationship between Sec14l3 mRNA/protein expression and allergic airway inflammation.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    SEC14-like protein 3
    Names
    45 kDa secretory protein
    SEC14-like 3
    rsec45
    secretory protein, 45kD

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022608.1 → NP_072130.1  SEC14-like protein 3

      See identical proteins and their annotated locations for NP_072130.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162038
      UniProtKB/TrEMBL
      A0A0G2JWI8, B1WC82
      Related
      ENSRNOP00000093206.2, ENSRNOT00000113444.2
      Conserved Domains (2) summary
      smart00516
      Location:76 → 245
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:13 → 59
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      83168154..83181240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092398.2 → XP_038948326.1  SEC14-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JWI8
      Related
      ENSRNOP00000101952.1, ENSRNOT00000165838.1
      Conserved Domains (2) summary
      smart00516
      Location:76 → 213
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:13 → 59
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1J8.1 GenPept UniProtKB/Swiss-Prot:Q9Z1J8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools