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    Apool apolipoprotein O-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317191, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Apoolprovided by RGD
    Official Full Name
    apolipoprotein O-likeprovided by RGD
    Primary source
    RGD:1549725
    See related
    EnsemblRapid:ENSRNOG00000082020 AllianceGenome:RGD:1549725
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1549725
    Summary
    Predicted to be involved in cristae formation. Predicted to be located in mitochondrion. Predicted to be part of MICOS complex. Orthologous to human APOOL (apolipoprotein O like). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 253.9), Muscle (RPKM 157.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Apool in Genome Data Viewer
    Location:
    Xq31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (81569960..81635906)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (77377723..77443672)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (83678269..83750550)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene serine and arginine rich splicing factor 10, pseudogene 1 Neighboring gene testis expressed gene 16 Neighboring gene ubiquitin-conjugating enzyme E2D 4 like 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 18 Neighboring gene spermidine/spermine N1-acetyl transferase-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitofilin complexes: conserved organizers of mitochondrial membrane architecture. Zerbes RM, et al. Biol Chem, 2012 Nov. PMID 23109542
    2. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. Ott C, et al. PLoS One, 2015. PMID 25781180, Free PMC Article
    3. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. Guarani V, et al. Elife, 2015 May 21. PMID 25997101, Free PMC Article
    4. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MICOS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MICOS complex subunit MIC27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014105.2 → NP_001014127.2  MICOS complex subunit MIC27 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      F1M7F3, Q5U1W6
      Related
      ENSRNOP00000099658.1, ENSRNOT00000162360.1

    2. NM_001393716.1 → NP_001380645.1  MICOS complex subunit MIC27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8J8YNE4, A6IV95, F1M7F3, Q5U1W6
      Conserved Domains (1) summary
      pfam09769
      Location:55 → 179
      ApoO; Apolipoprotein O

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      81569960..81635906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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