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    Acy1 aminoacylase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300981, updated on 27-Nov-2024

    Summary

    Official Symbol
    Acy1provided by RGD
    Official Full Name
    aminoacylase 1provided by RGD
    Primary source
    RGD:2030
    See related
    EnsemblRapid:ENSRNOG00000011189 AllianceGenome:RGD:2030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Acy1a; Acy1b
    Summary
    Enables aminoacylase activity. Predicted to be involved in protein catabolic process. Predicted to be located in extracellular exosome. Orthologous to human ACY1 (aminoacylase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 2160.4), Liver (RPKM 244.3) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Acy1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115951068..115956471, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107072354..107077756, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (115134792..115140171, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 Neighboring gene uncharacterized LOC120094254 Neighboring gene POC1 centriolar protein A Neighboring gene uncharacterized LOC134480228 Neighboring gene dual specificity phosphatase 7 Neighboring gene abhydrolase domain containing 14A Neighboring gene abhydrolase domain containing 14b

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminoacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aminoacylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables aminoacylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables aminoacylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    aminoacylase-1A
    Names
    ACY IA
    ACY IB
    ACY-1A
    ACY-1B
    N-acyl-L-amino-acid amidohydrolase
    aminoacylase-1B
    NP_001005383.2
    NP_001380767.1
    XP_063121307.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005383.2NP_001005383.2  aminoacylase-1A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q6AYS7, Q6PTT1
      UniProtKB/TrEMBL
      A0A8I5ZVF1
      Related
      ENSRNOP00000090917.2, ENSRNOT00000112946.2
      Conserved Domains (1) summary
      cd05646
      Location:9399
      M20_AcylaseI_like; M20 Aminoacylase-I like subfamily
    2. NM_001393838.1NP_001380767.1  aminoacylase-1A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q6AYS7, Q6PTT1
      UniProtKB/TrEMBL
      A0A8I5ZVF1
      Related
      ENSRNOP00000082264.2, ENSRNOT00000103409.2
      Conserved Domains (1) summary
      cd05646
      Location:9399
      M20_AcylaseI_like; M20 Aminoacylase-I like subfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      115951068..115956471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265237.1XP_063121307.1  aminoacylase-1A isoform X1