Crisp2 cysteine-rich secretory protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crisp2provided by MGI
Official Full Name: cysteine-rich secretory protein 2provided by MGI
Primary source: MGI:MGI:98815
See related: Ensembl:ENSMUSG00000023930 AllianceGenome:MGI:98815
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tpx1; Tpx-1; GAPDL5; CRISP-2
Summary: Predicted to be involved in cell-cell adhesion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CRISP2 (cysteine rich secretory protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 326.9) See more
Orthologs: human all
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Genomic context

Location:: 17 B2; 17 19.54 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (41075625..41105037, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (40764734..40794146, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we revealed a role for CRISP2 in establishing the ability of sperm to undergo the acrosome reaction and in establishing a normal flagellum waveform. Crisp2-deficient sperm possess a stiff midpiece and are thus unable to manifest the rapid form of progressive motility seen in wild type sperm. As a consequence, Crisp2-deficient males are subfertile.
Title: CRISP2 Is a Regulator of Multiple Aspects of Sperm Function and Male Fertility.
Crisp2 genetic defects in sperm from humans and mice result in male infertility.
Title: Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: implications for fertility disorders.
expression and localization of SHTAP in testis and sperm raise the possibility that the SHTAP-CRISP2 complex has a potential role in sperm formation and/or function.
Title: A novel protein, sperm head and tail associated protein (SHTAP), interacts with cysteine-rich secretory protein 2 (CRISP2) during spermatogenesis in the mouse.
These data raise the possibility that CRISP2 is a MAP3K11-modifying protein or, alternatively, that MAP3K11 acts to phosphorylate CRISP2 during acrosome development.
Title: Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm.
Evidence for a functional role of CRISP2 in fertilization.
Title: Evidence for the involvement of testicular protein CRISP2 in mouse sperm-egg fusion.
Tpx-1 Crisp domain on its own can regulate ion channel activity and provide compelling evidence for a role for Tpx-1 in the regulation of Ca(2+) fluxes observed during sperm capacitation.
Title: The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cysteine-rich secretory protein 2

Names: testis specific gene 1; testis-specific protein TPX-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001204071.1 → NP_001191000.1 cysteine-rich secretory protein 2 precursor

See identical proteins and their annotated locations for NP_001191000.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC135084, BC049615, CJ046590

Consensus CDS

CCDS28786.1

UniProtKB/Swiss-Prot

P16563

Conserved Domains (2) summary

cd05383
Location:36 → 171

SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...

pfam08562
Location:189 → 243

Crisp; Crisp
NM_009420.2 → NP_033446.1 cysteine-rich secretory protein 2 precursor

See identical proteins and their annotated locations for NP_033446.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC135084, BC049615

Consensus CDS

CCDS28786.1

UniProtKB/Swiss-Prot

P16563

Related

ENSMUSP00000024724.8, ENSMUST00000024724.14

Conserved Domains (2) summary

cd05383
Location:36 → 171

SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...

pfam08562
Location:189 → 243

Crisp; Crisp

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

41075625..41105037 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524036.3 → XP_006524099.1 cysteine-rich secretory protein 2 isoform X1

Conserved Domains (2) summary

pfam08562
Location:128 → 182

Crisp

cl00133
Location:1 → 111

CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family
XM_030249644.1 → XP_030105504.1 cysteine-rich secretory protein 2 isoform X1

Conserved Domains (2) summary

pfam08562
Location:128 → 182

Crisp

cl00133
Location:1 → 111

CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family