Wnt5b wingless-type MMTV integration site family, member 5B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnt5bprovided by MGI
Official Full Name: wingless-type MMTV integration site family, member 5Bprovided by MGI
Primary source: MGI:MGI:98959
See related: Ensembl:ENSMUSG00000030170 AllianceGenome:MGI:98959
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wnt-5b
Summary: Enables signaling receptor binding activity. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of fat cell differentiation. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human WNT5B (Wnt family member 5B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 4.7), limb E14.5 (RPKM 3.9) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 56.86 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (119409493..119521847, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (119432531..119544824, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation.
Title: Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation.
Results found that WNT-5B expression level is enhanced in ageing mice. WNT-5B repress the growth of lung organoid co-cultures of fibroblasts and epithelial progenitors, and preferentially restraining both the growth and differentiation of the alveolar epithelial progenitors. These results provide evidence that WNT-5B, along with WNT-5A negatively regulate the canonical WNT signaling pathway in alveolar epithelium.
Title: Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors.
opposing gradients of Wnt5a and Wnt5b and of their Sfrp inhibitors, together with intercellular signaling via planar cell polarity proteins, polarize node cells along the anterior-posterior axis for breaking of left-right symmetry.
Title: A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking.
Wnt5b activated known calcium-dependent signaling pathways and JNK, a component of the planar cell polarity pathway.
Title: Wnt5b regulates mesenchymal cell aggregation and chondrocyte differentiation through the planar cell polarity pathway.
this study aimed at defining the expression profile and function of Wnt5a and Wnt5b during adipogenesis by determining their effect on aP2 and PPARgamma expression and assessing the level of beta-catenin translocation in mouse 3T3-L1 preadipocytes.
Title: Wnt5b stimulates adipogenesis by activating PPARgamma, and inhibiting the beta-catenin dependent Wnt signaling pathway together with Wnt5a.
hCG was found to up-regulate these wnt ligands in mouse mammary gland, independent of the changes in ovarian steroidogenesis
Title: Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation.
Wnt5b may promote adipogenesis in 3T3-L1 cells, at least in part, by antagonizing the canonical Wnt/beta-catenin pathway
Title: Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes.
Secreted Wnt glycoproteins, expressed by thymic epithelial cells and thymocytes, regulate epithelial Foxn1 expression in both autocrine and paracrine fashions. Wnt molecules therefore provide regulatory signals critical for thymic function.
Title: Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice.
Data indicate that Wnt5a and Wnt5b control the pace of transitions between different chondrocyte zones.
Title: Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt5b (e-PCR), detects polymorphism
- UniSTS:508419

Wnt5b (e-PCR), detects polymorphism
- UniSTS:508420

Wnt5b (e-PCR), detects polymorphism
- UniSTS:465423

NoName (e-PCR)
- UniSTS:235536

Wnt5b (e-PCR), detects polymorphism
- UniSTS:471327

Wnt5b (e-PCR), detects polymorphism
- UniSTS:527141

Wnt5b (e-PCR), detects polymorphism
- UniSTS:277886

Wnt5b (e-PCR), detects polymorphism
- UniSTS:144782

RH133478 (e-PCR)
- UniSTS:216761

Wnt5b (e-PCR), detects polymorphism
- UniSTS:507321

AW545702 (e-PCR)
- UniSTS:179448

M89799 (e-PCR)
- UniSTS:179449

AW322056 (e-PCR)
- UniSTS:179450

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within animal organ morphogenesis	TAS Traceable Author Statement more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell signaling	TAS Traceable Author Statement more info	PubMed
involved_in muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of convergent extension involved in gastrulation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of non-canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-5b

Names: wingless-related MMTV integration site 5B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271757.2 → NP_001258686.1 protein Wnt-5b precursor

See identical proteins and their annotated locations for NP_001258686.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.

Source sequence(s)

AC126607

Consensus CDS

CCDS20474.2

UniProtKB/Swiss-Prot

P22726, Q91XF5

UniProtKB/TrEMBL

D3YTW9

Related

ENSMUSP00000113188.2, ENSMUST00000117171.8

Conserved Domains (1) summary

pfam00110
Location:54 → 359

wnt; wnt family
NM_001271758.2 → NP_001258687.1 protein Wnt-5b precursor

See identical proteins and their annotated locations for NP_001258687.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.

Source sequence(s)

AC126607

Consensus CDS

CCDS20474.2

UniProtKB/Swiss-Prot

P22726, Q91XF5

UniProtKB/TrEMBL

D3YTW9

Related

ENSMUSP00000112819.2, ENSMUST00000118120.8

Conserved Domains (1) summary

pfam00110
Location:54 → 359

wnt; wnt family
NM_001410505.1 → NP_001397434.1 protein Wnt-5b precursor

Status: VALIDATED

Source sequence(s)

AC126607, AC128662

UniProtKB/Swiss-Prot

P22726, Q91XF5

UniProtKB/TrEMBL

D3YTW9
NM_009525.4 → NP_033551.2 protein Wnt-5b precursor

See identical proteins and their annotated locations for NP_033551.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.

Source sequence(s)

AC126607, AC128662

Consensus CDS

CCDS20474.2

UniProtKB/Swiss-Prot

P22726, Q91XF5

UniProtKB/TrEMBL

D3YTW9

Related

ENSMUSP00000137065.2, ENSMUST00000178696.8

Conserved Domains (1) summary

pfam00110
Location:54 → 359

wnt; wnt family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

119409493..119521847 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036166025.1 → XP_036021918.1 protein Wnt-5b isoform X1

UniProtKB/TrEMBL

D3YTW9

Conserved Domains (1) summary

cd19348
Location:83 → 394

Wnt_Wnt5b; Wnt domain found in protein Wnt-5b and similar proteins
XM_036166026.1 → XP_036021919.1 protein Wnt-5b isoform X2

UniProtKB/TrEMBL

A0A0R4J1M1, D3YTW9

Conserved Domains (1) summary

cd19348
Location:61 → 372

Wnt_Wnt5b; Wnt domain found in protein Wnt-5b and similar proteins