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    Psg19 pregnancy specific glycoprotein 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psg19provided by RGD
    Official Full Name
    pregnancy specific glycoprotein 19provided by RGD
    Primary source
    RGD:2334
    See related
    EnsemblRapid:ENSRNOG00000038101 AllianceGenome:RGD:2334
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CEAC; Cea3; Cgm3; RATCEAC
    Summary
    Involved in female pregnancy. Predicted to be active in external side of plasma membrane. Orthologous to human CEACAM7 (CEA cell adhesion molecule 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Psg19 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (87549234..87559500, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78421183..78431449, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (79680194..79690460, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099773 Neighboring gene uncharacterized LOC120099774 Neighboring gene phosphoglycerate dehydrogenase, pseudogene 2 Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 3-like Neighboring gene FKBP prolyl isomerase 1A, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of two promoters of a rat pregnancy-specific glycoprotein gene. Chen H, et al. Biochemistry, 1994 Aug 16. PMID 8068638
    2. Identification of a carcinoembryonic antigen gene family in the rat. Analysis of the N-terminal domains reveals immunoglobulin-like, hypervariable regions. Kodelja V, et al. J Biol Chem, 1989 Apr 25. PMID 2708349
    3. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, et al. Genome Res, 2004 Apr. PMID 15060019, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114333

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in female pregnancy IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carcinoembryonic antigen gene family (CGM3)
    Names
    pregnancy-specific glycoprotein (rnCGM3)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270654.1 → NP_001257583.1  carcinoembryonic antigen gene family (CGM3) isoform 2 precursor

      See identical proteins and their annotated locations for NP_001257583.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D4A4A3, Q4V8L4
      Related
      ENSRNOP00000054796.4, ENSRNOT00000057986.6
      Conserved Domains (3) summary
      cd05774
      Location:156 → 260
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:45 → 136
      IG_like; Immunoglobulin like
      cl11960
      Location:262 → 352
      Ig; Immunoglobulin domain

    2. NM_019126.2 → NP_061999.2  carcinoembryonic antigen gene family (CGM3) precursor

      See identical proteins and their annotated locations for NP_061999.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J8H4, G3V9P5, Q62664
      Related
      ENSRNOP00000054798.4, ENSRNOT00000057988.7
      Conserved Domains (3) summary
      cd05774
      Location:156 → 260
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:45 → 136
      IG_like; Immunoglobulin like
      cl11960
      Location:382 → 472
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      87549234..87559500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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