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    Ergic2 ERGIC and golgi 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297728, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ergic2provided by RGD
    Official Full Name
    ERGIC and golgi 2provided by RGD
    Primary source
    RGD:1310606
    See related
    EnsemblRapid:ENSRNOG00000001852 AllianceGenome:RGD:1310606
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310606
    Summary
    Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be located in Golgi apparatus; endoplasmic reticulum-Golgi intermediate compartment; and nucleolus. Predicted to be part of retrograde transporter complex, Golgi to ER. Predicted to be active in COPII-coated ER to Golgi transport vesicle; endoplasmic reticulum; and membrane. Orthologous to human ERGIC2 (ERGIC and golgi 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 325.1), Heart (RPKM 248.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ergic2 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (182822225..182858392, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (181090808..181123074, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (182569086..182600258, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486874 Neighboring gene uncharacterized LOC108350795 Neighboring gene fatty acyl CoA reductase 2 Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 1 Neighboring gene ribosomal protein S4, X-linked, pseudogene 13 Neighboring gene thymosin beta-10-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The possible interaction of CDA14 and protein elongation factor 1alpha. Yang YF, et al. Biochim Biophys Acta, 2008 Feb. PMID 17980171
    2. WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. Yu J, et al. Dev Cell, 2014 May 12. PMID 24768165
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of retrograde transporter complex, Golgi to ER ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transporter complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum-Golgi intermediate compartment protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394930.1 → NP_001381859.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2JYN4, A6IN52
      Related
      ENSRNOP00000070726.1, ENSRNOT00000079291.3
      Conserved Domains (2) summary
      pfam07970
      Location:170 → 332
      COPIIcoated_ERV; Endoplasmic reticulum vesicle transporter
      pfam13850
      Location:13 → 95
      ERGIC_N; Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

    2. NM_001394931.1 → NP_001381860.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RNA

    1. NR_172212.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      182822225..182858392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285924.1 → XP_063141994.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYN4, A6IN52

    2. XM_063285922.1 → XP_063141992.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYN4, A6IN52

    3. XM_063285925.1 → XP_063141995.1  endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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