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    Mzt2 mitotic spindle organizing protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 72083, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mzt2provided by MGI
    Official Full Name
    mitotic spindle organizing protein 2provided by MGI
    Primary source
    MGI:MGI:1922845
    See related
    Ensembl:ENSMUSG00000022671 AllianceGenome:MGI:1922845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam128; Fam128b; 2410018G20Rik; 2610001E06Rik
    Summary
    Predicted to be located in cytosol and nucleoplasm. Predicted to be part of gamma-tubulin ring complex. Predicted to be active in centrosome and spindle. Orthologous to several human genes including MZT2A (mitotic spindle organizing protein 2A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 89.7), subcutaneous fat pad adult (RPKM 15.9) and 26 other tissues See more
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    Genomic context

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    See Mzt2 in Genome Data Viewer
    Location:
    16 A2; 16 10.09 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (15666305..15681233, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (15848441..15863369, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40212 Neighboring gene minichromosome maintenance complex component 4 Neighboring gene protein kinase, DNA activated, catalytic polypeptide Neighboring gene predicted gene, 52255 Neighboring gene STARR-seq mESC enhancer starr_40215 Neighboring gene STARR-seq mESC enhancer starr_40216 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:15863142-15863251 Neighboring gene STARR-positive B cell enhancer ABC_E5527 Neighboring gene STARR-seq mESC enhancer starr_40217 Neighboring gene predicted gene, 41425 Neighboring gene 60S ribosomal protein L30-like Neighboring gene CCAAT/enhancer binding protein delta Neighboring gene scaffolding protein involved in DNA repair

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
    2. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
    3. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of gamma-tubulin ring complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of gamma-tubulin ring complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mitotic-spindle organizing protein 2
    Names
    family with sequence similarity 128, member B
    mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2
    mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359003.1 → NP_001345932.1  mitotic-spindle organizing protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154586
      Consensus CDS
      CCDS27979.1
      UniProtKB/Swiss-Prot
      Q9CQ25
      Related
      ENSMUSP00000113832.2, ENSMUST00000117136.2
      Conserved Domains (1) summary
      pfam12926
      Location:16 → 98
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

    2. NM_029354.3 → NP_083630.1  mitotic-spindle organizing protein 2

      See identical proteins and their annotated locations for NP_083630.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154586
      Consensus CDS
      CCDS27979.1
      UniProtKB/Swiss-Prot
      Q9CQ25
      Related
      ENSMUSP00000023351.5, ENSMUST00000023351.11
      Conserved Domains (1) summary
      pfam12926
      Location:16 → 98
      MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      15666305..15681233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ25.1 GenPept UniProtKB/Swiss-Prot:Q9CQ25

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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