c6.L complement C6, gene 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: c6.L
Official Full Name: complement C6, gene 1 L homeolog
Primary source: Xenbase:XB-GENE-5961456
Locus tag: XELAEV_18008333mg
See related: EnsemblRapid:ENSXLAG00005032160 AllianceGenome:Xenbase:XB-GENE-5961456
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: c6; c6.1; c6.1.L
Summary: Predicted to act upstream of or within complement activation, classical pathway; innate immune response; and killing of cells of another organism. Predicted to be located in extracellular region. Predicted to be part of membrane attack complex. Human ortholog(s) of this gene implicated in complement component 6 deficiency. Orthologous to human C6 (complement C6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: chromosome: 1L

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (213216252..213246608)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (200014610..200045030)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
acts_upstream_of_or_within complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within killing of cells of another organism	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of membrane attack complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: complement C6, gene 1 L homeolog

Names: complement component 6, gene 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091779.1 → NP_001085248.1 complement C6, gene 1 L homeolog precursor

See identical proteins and their annotated locations for NP_001085248.1

Status: PROVISIONAL

Source sequence(s)

BC071018

UniProtKB/TrEMBL

Q6IR82

Related

ENSXLAP00005096320.1, ENSXLAT00005098095.1

Conserved Domains (5) summary

cd00033
Location:648 → 704

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

smart00057
Location:866 → 934

FIMAC; factor I membrane attack complex

smart00209
Location:26 → 79

TSP1; Thrombospondin type 1 repeats

cd00112
Location:143 → 173

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam01823
Location:298 → 518

MACPF; MAC/Perforin domain