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    tcf4.L transcription factor 4 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 108718448, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tcf4.L
    Official Full Name
    transcription factor 4 L homeolog
    Primary source
    Xenbase:XB-GENE-17330534
    Locus tag
    XELAEV_18008423mg
    See related
    EnsemblRapid:ENSXLAG00005028593 AllianceGenome:Xenbase:XB-GENE-17330534
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    XE2.1; Xtcf4; tcf-4; Xtcf-4
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; Lynch syndrome; and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tcf4.L in Genome Data Viewer
    Location:
    chromosome: 1L
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (220575524..220853988)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (207412383..207692660)

    Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene WD repeat domain 7 L homeolog Neighboring gene thioredoxin like 1 L homeolog Neighboring gene coiled-coil domain containing 68 L homeolog Neighboring gene RAB27B, member RAS oncogene family L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      220575524..220853988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018266818.2 → XP_018122307.1  transcription factor 4 isoform X5

      UniProtKB/TrEMBL
      A0A8J0VFB0
      Conserved Domains (1) summary
      cd18945
      Location:562 → 646
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    2. XM_018266783.2 → XP_018122272.1  transcription factor 4 isoform X11

      UniProtKB/TrEMBL
      A0A8J0VF99

    3. XM_018266825.2 → XP_018122314.1  transcription factor 4 isoform X12

      UniProtKB/TrEMBL
      A0A8J0VN55
      Related
      ENSXLAP00005085571.1, ENSXLAT00005087233.1

    4. XM_041570061.1 → XP_041425995.1  transcription factor 4 isoform X7

      UniProtKB/TrEMBL
      A0A8J1LBF4
      Related
      ENSXLAP00005085388.1, ENSXLAT00005087050.1
      Conserved Domains (1) summary
      cd18945
      Location:524 → 608
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    5. XM_018266789.2 → XP_018122278.1  transcription factor 4 isoform X1

      UniProtKB/TrEMBL
      A0A8J0VI04

    6. XM_018266811.2 → XP_018122300.1  transcription factor 4 isoform X4

      UniProtKB/TrEMBL
      A0A8J0VN52

    7. XM_041570063.1 → XP_041425997.1  transcription factor 4 isoform X8

      UniProtKB/TrEMBL
      A0A8J1L8X5
      Conserved Domains (1) summary
      cd18945
      Location:502 → 586
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    8. XM_018266796.2 → XP_018122285.1  transcription factor 4 isoform X2

      UniProtKB/TrEMBL
      A0A8J0VI27

    9. XM_018266803.2 → XP_018122292.1  transcription factor 4 isoform X3

      UniProtKB/TrEMBL
      A0A8J0VI09
      Related
      ENSXLAP00005085466.1, ENSXLAT00005087128.1

    10. XM_018266828.2 → XP_018122317.1  transcription factor 4 isoform X6

      UniProtKB/TrEMBL
      A0A8J0VI35
      Related
      ENSXLAP00005085307.1, ENSXLAT00005086969.1

    11. XM_041570067.1 → XP_041426001.1  transcription factor 4 isoform X9

      UniProtKB/TrEMBL
      A0A8J1L913
      Conserved Domains (1) summary
      cd18945
      Location:498 → 582
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    12. XM_041570056.1 → XP_041425990.1  transcription factor 4 isoform X5

      UniProtKB/TrEMBL
      A0A8J0VFB0
      Conserved Domains (1) summary
      cd18945
      Location:562 → 646
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    13. XM_041570054.1 → XP_041425988.1  transcription factor 4 isoform X5

      UniProtKB/TrEMBL
      A0A8J0VFB0
      Conserved Domains (1) summary
      cd18945
      Location:562 → 646
      bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

    14. XM_018266841.2 → XP_018122330.1  transcription factor 4 isoform X10

      UniProtKB/TrEMBL
      A0A8J0VI20, A0A974E431

    15. XM_018266835.2 → XP_018122324.1  transcription factor 4 isoform X10

      UniProtKB/TrEMBL
      A0A8J0VI20, A0A974E431
      Related
      ENSXLAP00005085157.1, ENSXLAT00005086819.1

    16. XM_018266845.2 → XP_018122334.1  transcription factor 4 isoform X13

      UniProtKB/TrEMBL
      A0A8J0VI25, A0A974E431

    17. XM_018266850.2 → XP_018122339.1  transcription factor 4 isoform X14

      UniProtKB/TrEMBL
      A0A8J0VN62, A0A974E431

    18. XM_018266854.2 → XP_018122343.1  transcription factor 4 isoform X15

      UniProtKB/TrEMBL
      A0A8J0VI45, A0A974E431
    Nucleotide Protein Strain
    Heading Accession and Version

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