rev1.S REV1, DNA directed polymerase S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: rev1.S
Official Full Name: REV1, DNA directed polymerase S homeolog
Primary source: Xenbase:XB-GENE-968200
Locus tag: XELAEV_18015539mg
See related: EnsemblRapid:ENSXLAG00005033576 AllianceGenome:Xenbase:XB-GENE-968200
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: rev1
Summary: Predicted to enable damaged DNA binding activity; metal ion binding activity; and nucleotidyltransferase activity. Predicted to act upstream of or within error-free translesion synthesis and error-prone translesion synthesis. Predicted to be located in nucleus. Orthologous to human REV1 (REV1 DNA directed polymerase). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2S

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (103613992..103659914)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (94521140..94567458)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rev1 binds specifically to the DNA interstrand cross-links locus during DNA lesion bypass.Binding of Rev1 to the DNA interstrand cross-links locus is dependent on the Fanconi anemia core complex.
Title: Regulation of the Rev1-pol ζ complex during bypass of a DNA interstrand cross-link.
ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.
Title: REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within error-prone translesion synthesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: REV1, DNA directed polymerase S homeolog

Names: REV1 homolog; REV1, polymerase (DNA directed)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091444.1 → NP_001084913.1 REV1, DNA directed polymerase S homeolog

See identical proteins and their annotated locations for NP_001084913.1

Status: PROVISIONAL

Source sequence(s)

BC070743

UniProtKB/TrEMBL

Q6NRK6

Related

ENSXLAP00005100322.1, ENSXLAT00005102277.1

Conserved Domains (5) summary

cd01701
Location:347 → 812

PolY_Rev1; DNA polymerase Rev1

PRK14133
Location:408 → 821

PRK14133; DNA polymerase IV; Provisional

smart00292
Location:49 → 121

BRCT; breast cancer carboxy-terminal domain

pfam14377
Location:923 → 1024

DUF4414; Domain of unknown function (DUF4414)

pfam16727
Location:1116 → 1229

REV1_C; DNA repair protein REV1 C-terminal domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

103613992..103659914

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018248189.2 → XP_018103678.1 REV1, DNA directed polymerase S homeolog isoform X1

UniProtKB/TrEMBL

A0A1L8H8Q0, A0A974DI74
XM_041583072.1 → XP_041439006.1 REV1, DNA directed polymerase S homeolog isoform X2

UniProtKB/TrEMBL

A0A8J1MCC2

Conserved Domains (2) summary

cd01701
Location:143 → 608

PolY_Rev1; DNA polymerase Rev1

cd12145
Location:932 → 1025

Rev1_C; C-terminal domain of the Y-family polymerase Rev1